| 银屑病与白细胞介素-17和白细胞介素-10表达水平的相关研究 |
| |
| 引用本文： | 张宏宇,;毛祖豪,;陈晓芬. 银屑病与白细胞介素-17和白细胞介素-10表达水平的相关研究[J]. 中国医师进修杂志, 2014, 0(33): 19-20 |
| |
| 作者姓名： | 张宏宇, 毛祖豪, 陈晓芬 |
| |
| 作者单位： | [1]广州市白云区人民医院皮肤科,510500; [2]南方医科大学第三附属医院皮肤科,广州510630 |
| |
| 基金项目： | 2012年广东省社会发展领域科技计划（20120318087） |
| |
| 摘 要： | 目的 探讨银屑病与白细胞介素（IL）-17、IL-10表达的相关性.方法 采用酶联免疫吸附试验法检测32例银屑病患者（银屑病组）和30例健康体检者（对照组）血清IL-17和IL-10水平,并进行相关性分析.结果 银屑病组血清IL-17水平高于对照组[（57.59±11.99） ng/L比（33.27 ±6.49） ng/L],IL-10水平低于对照组[（25.38 ±4.32） ng/L比（32.01±5.54）n g/L],差异均有统计学意义（￡=9.84,5.27,P＜0.01）.银屑病患者血清IL-17与IL-10呈负相关（r=-0.70,P＜0.01）.结论 银屑病发病可能与IL-17、IL-10水平的失衡存在一定关联.
|
| 关 键 词： | 银屑病 白细胞介素17 白细胞介素10 |
Correlation of the expression of interleukin-17 and interleukin-10 in psoriasis |
| |
| Affiliation: | Zhang Hongyu, Mao Zuhao, Chen Xiaofen (Department of Dermatology, the Thinl Affiliated Hospital of Southern Medical University, Guangzhou 510630, China) |
| |
| Abstract: | Objective To investigate the relationship between interleukin （IL）-17 and IL-10 in psoriasis.Methods The expression of IL-17 and IL-10 was measured by enzyme-linked immunosorbent assay in 32 patients with psoriasis （psoriasis group） and 30 normal controls （control group）.The correlation of IL-17 and IL-10 was analyzed.Results The expression of IL-17 in psoriasis group was higher than that in control group[（57.59 ± 11.99） ng/L vs.（33.27 ± 6.49） ng/L] （t =9.84,P 〈 0.01）.The expression of IL-10 in psoriasis group was lower than that in control group [（25.38 ± 4.32） ng/L vs.（32.01 ± 5.54） ng/L] （t =5.27,P〈 0.01）.There was negative correlation between IL-17 and IL-10 in patients with psoriasis （r =-0.70,P 〈 0.01）.Conclusion The pathogenesis of psoriasis may be related to imbalance of IL-17 and IL-10. |
| |
| Keywords: | Psoriasis Interleukin-17 Interleukin-10 |
| 本文献已被 维普 等数据库收录！ |
|
