不同剂量盐酸氨溴索治疗慢性阻塞性肺疾病急性加重期老年患者的疗效比较

目的 研究不同剂量盐酸氨溴索治疗慢性阻塞性肺疾病急性加重期（AECOPD）老年患者的疗效.方法 选择在温岭市康复医院内科住院的AECOPD老年患者104例,根据住院顺序随机分为大剂量组和小剂量组,各52例.2组患者均接受吸氧、解痉、抗感染等常规治疗,大剂量组患者在此基础上静脉滴注盐酸氨溴索120 mg/d,小剂量组患者静脉滴注盐酸氨溴索60 mg/d.连续治疗1周后,观察2组患者的临床表现、血气等指标的改善情况.结果 大剂量组的总有效率为90.4％ （47/52）,小剂量组的总有效率71.2％ （37/52）,组间差异有统计学意义（P＜0.05）.治疗后2组患者的氧分压和二氧化碳分压相比较,大剂量组指标明显优于小剂量组（65.2±2.7） mmHg（1 mmHg=0.133 kPa）比（60.9±2.2） mmHg,（46.2±3.0） mmHg比（50.1 ±2.7）mmHg],差值差异有统计学意义（11.7±1.9） mmHg比（10.5±1.6） mmHg,（12.57±0.22） mmHg比（12.15 ±2.67）mmHg] （P ＜0.05）.结论 大剂量盐酸氨溴索的临床疗效显著,可明显改善患者的症状.

Different dose of ambroxol on acute exacerbation of chronic obstructive pulmonary disease in elderly patients

Objective To study the different doses of ambroxol treating acute exacerbation of chronic obstructive pulmonary disease in elderly patients.Methods Totally 104 acute exacerbation chronic obstructive pulmonary disease patients were randomly divided into high-dose group and small-dose group;two groups were given oxygen inhalation,spasmolysis,antibiotics and other conventional treatments ; control group was given small dose ambroxol intravenous injection;the high-dose group had the conventional treatment.After 1 week of continuous treatment,the improvement of clinical symptoms and blood gas indexes was observed.Results The effective rate in high-dose group was 90.4% （47/52） ; the total effective rate of small dose group was 71.2% （37/52） ; the difference was statistically significant （P 〈 0.05）.After treatment,the partial pressure of oxygen and dioxide in high-dose group were obviously better than those in small dose group （65.2 ± 2.7） mmHg vs （60.9 ± 2.2） mmHg,（46.2 ± 3.0） mmHg vs （50.14 ± 2.68） mmHg; （11.7 ± 1.9） mmHg vs （10.5 ± 1.6） mmHg,（12.57 ± 0.22）mmHg vs （12.15 ±2.67）mmHg] （P〈0.05）.Conclusion The large dose of ambroxol can significantly improve the symptoms of acute exacerbation of chronic obstructive pulmonary disease in elderly patients.