胃癌患者根治术后预后因素分析

目的 分析影响胃癌根治术后患者预后的临床病理因素,提高对胃癌的认识及治疗水平,为临床诊治提供依据.方法 回顾性分析1999年1月至2009年12月收治并行标准胃癌根治术的胃癌患者的临床病理资料,符合标准的581例患者共随访到179例,建立数据库用SPSS 13.0软件进行分析.结果 单因素分析表明：胃癌根治术后患者预后影响因素包括年龄、肿瘤部位、肿瘤最大直径、大体类型、组织学类型、浸润深度、TNM分期、手术方式、标本切缘和淋巴结转移个数（P＜0.05或＜0.01）;性别与预后无相关性（P＞0.05）.多因素Cox回归分析提示：TNM分期和淋巴结转移个数是影响胃癌患者预后的独立因素,其中淋巴结转移个数是影响胃癌预后最重要的因素.结论 TNM分期和淋巴结转移个数是胃癌预后的独立影响因素,其中淋巴结转移个数是胃癌预后最为重要的影响因素,因此国际抗癌联盟的淋巴结分期是胃癌预后更好的判断指标.

Analysis of prognostic influencing factors for gastric cancer patients after radical resection

Objective To analyze the clinical and pathological factors that affect the prognosis of gastric cancer patients after radical resection,and study the relationship between biological behavior of gastric cancer and clinical so as to provide clues to the basis for clinical diagnosis and treatment.Methods The clinical and pathological data of the gastric cancer patients who underwent radical resection from January 1999 to December 2009 were retrospectively analyzed.Of the 581 eligible patients were followed up in 179 cases.A database was established for SPSS 13.0 software analysis.Results Single factor analysis showed that the prognosis influencing factors in gastric cancer patients after radical resection were age,tumor location,tumor size,gross type,histological type,depth of invasion,TNM stage,surgical procedure,the cancerous remains of specimen surgical margin and the number of lymph node metastasis （P 〈 0.05 or 〈 0.01）,no correlation was found between gender and prognosis （P 〉 0.05）.Multiple Cox regression analysis showed that TNM stage and number of lymph node metastasis were independent gastric cancer prognostic influencing factors,and the number of lymph node metastasis was found to be the more significant factor.Conclusions TNM stage and the number of lymph node metastasis are independent prognostic influencing factors in gastric cancer,and the number of lymph node metastasis is the more important factor in gastric cancer prognosis.Therefore,Union for International Cancer Control lymph node staging of gastric cancer is a better indicator for gastric cancer prognosis.