支气管哮喘患儿25-羟维生素D3及总IgE水平检测分析

目的 探讨25-羟维生素D3[25-（OH）D3]及总IgE （TIgE）在儿童支气管哮喘发病过程中的作用.方法 选取22例支气管哮喘患儿（支气管哮喘组）及20例健康体检儿童（对照组）,测定比较两组血清25-（OH）D3及TIgE水平.结果 支气管哮喘组血清25-（OH）D3为（23.64±3.89）μg/L,明显低于对照组的（35.82±4.37）μg/L,差异有统计学意义（P＜0.05）.支气管哮喘组血清TIgE为（208.62±32.59） kU/L,明显高于对照组的（73.84±18.86） kU/L,差异有统计学意义（P＜0.05）.支气管哮喘组血清25-（OH）D3与血清TIgE呈负相关（r=-0.832,P＜ 0.01）,对照组血清25-（OH）D3与血清TIgE无相关性（r=-0.038,P＞0.05）.结论 25-（OH）D3的缺乏与变态反应密切相关,可能在支气管哮喘发病中有重要作用,监测其水平变化有助于评估支气管哮喘患儿的病情.

The study of relationship between serum levels of 25-hydroxyvitamin D3 and total IgE in children with bronchial asthma

Objective To study the effect of the serum levels of 25-hydroxyvitamin D3 [25-（OH）D3] and total IgE （TIgE） in pathogenesis of the children bronchial asthma.Methods Twenty-two children with bronchial asthma （bronchial asthma group） and 20 healthy children （control group） were selected.The serum levels of 25-（OH）D3 and TIgE in the children of 2 groups were detected.Results The level of serum 25-（OH）D3 in bronchial asthma group was significantly lower than that in control group [（23.64 ± 3.89）μ g/L vs.（35.82 ± 4.37） μ g/L],there was statistical difference （P 〈 0.05）.The level of serum TIgE in bronchial asthma group was significantly higher than that in control group [（208.62 ± 32.59） kU/L vs.（73.84 ± 18.86） kU/L],there was statistical difference （P 〈 0.05）.There was negative correlation between the level of serum 25-（OH）D3 and TIgE in bronchial asthma group （r =-0.832,P 〈 0.01）,but there was no correlation between the level of serum 25-（OH）D3 and TIgE in control group （r =-0.038,P 〉0.05）.Conclusions The lack of 25-（OH）D3 may be associated with allergy and childhood bronchial asthma.By monitor the levels of 25-（OH）D3 and TIgE may assess condition of childhood bronchial asthma.