间苯三酚联合地西泮在第一产程活跃期应用疗效评价

目的 探讨间苯三酚联合地西泮治疗第一产程活跃期进展缓慢或停滞效果及围生期结局.方法 选择在宫口开大2～3cm后出现产程进展缓慢或活跃期停滞行阴道分娩的初产妇,按随机数字表法分成两组,每组100例,观察组应用间苯三酚80 mg和地西泮10 mg,对照组只应用地西泮10 mg,观察两组的宫口扩张情况、宫颈软硬及有无水肿,并记录宫口开全时间、第二产程时间、分娩方式、产后2h阴道出血总量及围生期新生儿结局等.结果 观察组宫口扩张速度（2.31±0.27）cm/h,从用药至宫口开全时间为（187.27±33.22） min.对照组宫口扩张速度（1.82±0.48） cm/h,从用药至宫口开全时间为（251.32±45.33） min,两组比较差异有统计学意义（P＜0.05）.观察组剖宫产率18.0％（18/100）,对照组剖宫产率32.0％（32/100）,两组比较差异有统计学意义（P＜0.05）.两组第二产程时间、产后2h阴道出血总量、新生儿窒息发生率比较差异无统计学意义（P＞0.05）.结论 间苯三酚联合地西泮应用在活跃期进展缓慢或停滞时疗效明显,能促进产程进展,提高阴道分娩率,减少剖宫产率,并对围生期结局无不良影响,值得推广.

Therapeutic effect evaluation of phloroglucinol combined with diazepam during active phase of first stage of labor

Objective To observe the therapeutic effect of phloroglucinol combined with diazepam in prolonged or protracted active phase of first stage of labor,and the outcome of perinatal phase.Methods Two hundred vaginal delivery primipara with prolonged or protracted active phase after dilatation of cervix 2-3 cm were selected.The patients were divided into 2 groups by random digits table method with 100 cases each,the patients in observation group were given phloroglucinol 80 mg and diazepam 10 mg,and the patients in control group were given diazepam 10 mg.The cervical dilatation,the degree soft hardness and edema of cervix,time of active phase,time of second stage of labor,mode of delivery,vaginal bleeding in 2 h postpartum and outcome of perinatal phase in the 2 groups were observed.Results In observation group,the cervical dilatation rate was （2.31 ± 0.27） cm/h,the time of active phase was （187.27 ± 33.22） min.In control group,the cervical dilatation rate was （1.82 ±0.48） cm/h,the time of active phase was （251.32 ± 45.33） min,there were statistical differences between 2 groups （P 〈 0.05）.The rate of uterineincision delivery in observation group was significantly lower than that in control group 18.0%（18/100） vs.32.0% （32/100）],there was statistical difference （P 〈 0.05）.There were no statistical differences in time of second stage of labor,vaginal bleeding in 2 h postpartum,rate of neonatal asphyxia between 2 groups （P 〉0.05）.Conclusion The effect of phloroglucinol combined with diazepam in prolonged or protracted active phase is remarkable,it can promote the progress of labor,speed up delivery progress,improve the rate of vaginal delivery and decrease the rate of uterine-incision delivery,and no adverse effects on the outcome of perinatal phase,it is worth popularizing.