血清同型半胱氨酸及高敏C反应蛋白与冠心病相关性分析

目的：探讨血清同型半胱氨酸（ Hcy ）、高敏 C 反应蛋白（ hs-CRP ）与冠心病的相关性。方法测定111例冠心病患者组（冠心病组）及77例健康志愿者（健康对照组） Hcy、hs-CRP水平，分析其与冠心病的关系。应用循环酶法检测Hcy，应用免疫比浊法检测hs-CRP。冠心病组患者根据病情不同分为稳定型心绞痛（ SAP）组、不稳定型心绞痛（ UAP）组、急性心肌梗死（ AMI）组，分析各亚组Hcy、hs-CRP水平差异性。结果冠心病组患者血清Hcy、hs-CRP水平明显高于健康对照组（21±9）μmol/L比（9±6）μmol/L，（15．1±1．4）mg/L比（1．0±0．9）mg/L]（P＜0．05）。冠心病各亚组比较：AMI组患者血清Hcy、hs-CRP水平明显高于SAP组及UAP组（24±8）μmol/L比（16±5）、（19±6）μmol/L，（23．7±5．9）mg/L比（4．0±3．0）、（15．4±3．2）mg/L]（P＜0．05）。 UAP组患者血清Hcy水平、血清hs-CRP水平明显高于SAP组（19±6）μmol/L 比（16±5）μmol/L，（15．4±3．2） mg/L 比（4．0±3．0） mg/L]（P ＜0．05）。结论血清Hcy及hs-CRP水平与冠心病病情相一致，检测血清Hcy及hs-CRP水平可以判断冠心病病情，对于指导治疗有积极的意义。

Correlation analysis of serum homocysteine or high sensitivity C reactive protein and coronary heart dis-ease

Objective To investigate the correlation of serum homocysteine （ Hcy） or high sensitivity C reactive protein （ hs-CRP） and coronary heart disease .Methods Serum Hcy and hs-CRP levels in 111 cases of coronary heart disease and 77 cases of healthy volunteers were measured and analyzed .Determination of serum Hcy was done by enzymatic cycling assay and determination of serum hs-CRP was done by immunoturbidimetric assay . 111 patients with coronary heart disease were divided into stable angina pectoris （ SAP group ） , unstable angina pectoris （ UAP group） and acute myocardial infarction （ AMI group） according to the conditions;the differences of Hcy and hs-CRP levels of each group were analyzed .Results Serum hcy level and serum hs-CRP levels in CHD group were significantly higher than those in the healthy control group （ 21 ±9 ）μmol/L vs （ 9 ±6 ）μmol/L, （15.1 ±1.4）mg/L vs （1.0 ±0.9）mg/L] （P〈0.05）.Serum Hcy levels and serum hs-CRP levels in AMI group were significantly higher than those in SAP group and UAP group （ 24 ±8 ）μmol/L vs （ 16 ±5 ）μmol/L, （19 ±6）μmol/L,（23.7 ±5.9）mg/L vs （4.0 ±3.0）mg/L,（15.4 ±3.2）mg/L]（P〈0.05）.Serum Hcy levels and serum hs-CRP levels in UAP group were significantly higher than those in SAP group （ 19 ±6 ）μmol/L vs （16 ±5）μmol/L,（15.4 ±3.2）mg/L vs （4.0 ±3.0）mg/L]（P〈0.05）.Conclusions Serum Hcy and hs-CRP levels are consistent with coronary heart disease .The condition of coronary heart disease can be judged by serum Hcy and hs-CRP levels, and it is good for guiding the treatment .