Enantioselective synthesis of no-carrier-added (NCA) 6-[18F]fluoro-L-DOPA. |
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| Authors: | Lan Zhang Ganhua Tang Duanzhi Yin Xiaolan Tang Yonxian Wang |
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| Affiliation: | Shanghai Institute of Nuclear Research, Chinese Academy of Sciences. zhangl@sina.com |
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| Abstract: | The application of a chiral phase-transfer-catalyst (PTC) in the synthesis of N.C.A. 6-[18F]fluoro-L-DOPA has been recently developed. The 6-trimethylammoniumveratraldehyde triflate precursor and PTC (O-allyl-N-(9)-anthracenylcinchonidinium bromide) were synthesized and successful synthesis route was developed for the preparation of 6-[18F]fluoro-L-DOPA with high radiochemical yields (4-9%, decay uncorrected) and short synthesis time (80min). The radiochemical purity was over 99% and no D-isomer was detected by HPLC analysis using a chiral mobile phase. |
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