| 3－酮－地索高诺酮的生物活性研究 |
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| 引用本文： | 蒋国庆,郑淑蓉,严仁英. 3－酮－地索高诺酮的生物活性研究[J]. 北京大学学报(医学版), 1996, 0(6) |
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| 作者姓名： | 蒋国庆 郑淑蓉 严仁英 |
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| 作者单位： | 北京医科大学第一医院妇产科 |
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| 摘 要： | 目的：测定３－酮－地索高诺酮在小鼠、大鼠和家兔体内的生物活性。方法：采用六点法或四点法生物检定。结果：３－酮－地索高诺酮具有很强的抗排卵活性，很高的孕激素活性，无明显的雌激素活性，有较强的抗雌激素活性，雄激素活性和同化激素活性很低。该药的生物活性选择系数明显高于左旋－１８－甲基炔诺酮，该药的生物活性选择性更专一，即保证很高孕激素活性的同时，雄激素活性进一步下降。结论：３－酮－地索高诺酮的临床应用在保证高效避孕作用的同时，可减少与雄激素活性有关的副作用。
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| 关 键 词： | 3－酮－地索高诺酮＊；避孕药，女用／药理学；排卵／药物作用；孕酮激素类 |
STUDY ON THE BIOLOGICAL ACTIVITIES OF 3-KETO-DESOGESTREL |
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| JIANG Guoqhg, ZHENG Shurong, YAN Renying. STUDY ON THE BIOLOGICAL ACTIVITIES OF 3-KETO-DESOGESTREL[J]. Journal of Peking University. Health sciences, 1996, 0(6) |
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| Authors: | JIANG Guoqhg ZHENG Shurong YAN Renying |
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| Abstract: | Objective:To determine the biological activities of 3-keto-desogestrel(KDG)in mouse,rats and rabbits. Methods:Four or six-point bioassay. Results:KDG was a contraceptive with strong an-tiovulation activity,very high progestogen activity,no estrogenic activity,high anti-estrogenic activity,and very low androgenic and anabolic activity.Selectivity index for biological activity of KDG was re-markably higher than that of levonorgestrel.Conclusion:KDG may be a more selective progestogen contraceptive and may produce less androgenic side-effects in clinical application. |
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| Keywords: | keto-desogestrel* Contraceptive agents female/pharmacal Ovulation/drug eff Pro-gestational hormones |
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