| 氧化苦参碱对皮肤疾病的药理作用与临床应用研究进展 |
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| 引用本文： | 张明发,沈雅琴.氧化苦参碱对皮肤疾病的药理作用与临床应用研究进展[J].现代药物与临床,2020,43(4):790-796. |
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| 作者姓名： | 张明发 沈雅琴 |
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| 作者单位： | 上海美优制药有限公司, 上海 201204 |
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| 摘 要： | 氧化苦参碱能抑制疤痕成纤维细胞增殖和胶原合成，并诱导凋亡和基质金属蛋白酶表达。氧化苦参碱能抑制皮肤癌细胞增殖并诱导凋亡，也能抑制表皮角质形成细胞增殖和黑素形成。氧化苦参碱对各种免疫性和非免疫性皮肤炎症均有抗炎作用，临床上已被试用于多种皮肤病的治疗。
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| 关 键 词： | 氧化苦参碱 皮炎 瘢痕 成纤维细胞 角质形成细胞 黑素生成 |
| 收稿时间： | 2020/1/14 0:00:00 |
Research progress on dermatopharmacology and clinic application of oxymatrine |
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| ZHANG Mingf,SHEN Yaqin.Research progress on dermatopharmacology and clinic application of oxymatrine[J].Drugs & Clinic,2020,43(4):790-796. |
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| Authors: | ZHANG Mingf SHEN Yaqin |
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| Institution: | Shanghai Meiyou Pharmaceutical Co. Ltd., Shanghai 201204, China |
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| Abstract: | Oxymatrine inhibits proliferation and collagen synthesis of scar fibroblasts, and induces apoptosis and expression of MMP. Oxymatrine inhibits proliferation and induces apoptosis of skin carcinoma cells, and too inhibits proliferation of epidermic keratinocyte and melanogenesis. Oxymatrine has anti-inflammatory effects against various immune and non-immune dermatitis. In clinic Oxymatrine has been tried on the treatment of various dermatitis. |
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| Keywords: | oxymatrine dermatitis scar fibroblast keratinocyte melanogenesis |
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