小金片联合亮丙瑞林治疗子宫内膜异位症的临床研究

目的探讨小金片联合亮丙瑞林治疗子宫内膜异位症的临床效果。方法选取2016年1月-2018年6月北京怀柔医院收治的子宫内膜异位症患者90例,随机分成对照组(45例)和治疗组(45例)。对照组皮下注射注射用醋酸亮丙瑞林微球,3.75mg/次,1次/4周,共治疗3次,初次给药从月经周期的第3天开始。治疗组在对照组基础上口服小金片,2片/次,2次/d。两组患者连续治疗3个月。观察两组患者临床疗效,同时比较治疗前后两组患者主要症状体征改善情况,及促卵泡刺激素(FSH)、促黄体生成素(LH)、雌二醇(E2)、全血低切黏度(LBV)、红细胞聚集指数(EAI)、红细胞比容(HCT)、肿瘤坏死因子-α(TNF-α)、单核细胞趋化蛋白-1(MCP-1)和糖蛋白抗原125(CA125)水平。结果治疗后,对照组和治疗组临床有效率分别为82.2%和95.6%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者痛经、盆腔痛、性交痛等VAS评分均显著降低(P<0.05),盆腔包块直径、子宫体积则均显著缩小(P<0.05),且治疗组以上主要症状体征的改善效果均显著优于对照组(P<0.05)。治疗后,两组血清FSH、LH、E2水平均显著降低(P<0.05),且治疗组比对照组下降更显著(P<0.05)。治疗后,治疗组LBV、EAI、HCT值均显著低于对照组(P<0.05)。治疗后,两组患者血清TNF-α、MCP-1及CA125浓度均显著下降(P<0.05);且治疗组较同期对照组下降更明显(P<0.05)。结论小金片联合亮丙瑞林治疗子宫内膜异位症有助于促进患者相关症状体征的缓解,调节生殖内分泌功能,改善机体淤血及炎症状态,整体疗效显著,安全可靠。

Clinical study on Xiaojin Tablets combined with leuprorelin in treatment of endometriosis

Objective In order to provide clinical evidence for the new role of old drugs, systematically evaluate the curative effect of lidocaine on tinnitus. Methods The clinical randomized controlled trials (RCTs) about lidocaine in treatment of subjective tinnitus in Pubmed, Embase, Cochrane Central, CNKI, CBM, VIP and Wanfang database were searched until June 2019 by computer. Data statistics were conducted by Review Manager 5.3 software. Results A total of 17 RCTs articles and 1 691 patients (1 737 ears) were included. The control group includes 842 cases and the experimental group is 859 cases. Meta-analysis result shows that lidocaine has a higher therapeutic effect on tinnitus than traditional therapies (95%CI=2.44~3.97, OR=3.11, Z=9.12, P<0.000 01). Conclusion Lidocaine can significantly relieve the symptoms of tinnitus in patients and has a strong clinical application value.