活性蛋白质组技术应用于中药活性分子靶点的研究进展

活性蛋白质组技术（ABPP）是越来越多的化学蛋白质组学方法之一，该技术利用小分子化学探针来探索化合物和靶点之间的相互作用机制。在中药活性成分分子靶点的鉴定中，ABPP技术具有高效、准确等优越性，目前已经利用该技术鉴定了许多中药活性成分的分子靶点。综述了ABPP技术在中药活性分子靶点中的应用，包括青蒿素、黄芩苷、穿心莲内酯、苏木酮、龙牙葱木皂苷、山楂酸、蟾毒内酯、毛兰素与荜茇宁等，为创新药物靶点的发现提供新的思路。

Application of active proteome technology in molecular target research of active components of traditional Chinese medicine

The activity-based proteome technique (ABPP) is one of the growing number of chemical proteomics methods that exploit small molecular chemical probes to explore the mechanisms of interaction between compounds and targets. The technology has been used to identify many molecular targets of active components of traditional Chinese medicine. The application of ABP technology in the molecular targets of active components of traditional Chinese medicine, including artemisinin, baicalin, andrographolide, hematoxylone, scallion saponins, hawthorn acid, toadlactone, maulanin and piper longone were reviewed, in order to provide new ideas for the development of traditional Chinese medicine and the discovery of innovative drug targets.