| 肿瘤坏死因子启动子基因多态性与哮喘的相关性 |
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| 引用本文： | 赵海军,丁亚春,刘娅,史杰萍,刘华锋,张婕,成焕吉,崔燕南,侯松萍.肿瘤坏死因子启动子基因多态性与哮喘的相关性[J].吉林大学学报(医学版),2005,31(3):449-451. |
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| 作者姓名： | 赵海军 丁亚春 刘娅 史杰萍 刘华锋 张婕 成焕吉 崔燕南 侯松萍 |
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| 作者单位： | 1. 吉林大学公共卫生学院营养与食品卫生学教研室, 吉林 长春130021;2. 吉林大学公共卫生学院流行病学教研室，吉林 长春130021;3. 吉林大学第二医院呼吸内科, 吉林 长春130041;4. 吉林大学第一医院儿科, 吉林 长春130 |
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| 基金项目： | 吉林省长春市科技局资助项目 |
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| 摘 要： | 目的：探讨肿瘤坏死因子启动子（TNF-308）基因多态性与哮喘发病之间的关系。方法：采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）方法研究了50例哮喘患者和80例健康对照者TNF-308等位基因和基因型的分布情况。
结果：TNF-308等位基因在哮喘组和健康对照组之间的分布差异无显著性（χ2=0.047，P>0.05）。同时，TNF-308的3种基因型(GG、GA和AA)在哮喘组（45/50，5/50和0/50 ）和健康对照组（71/80、9/80和0/80）的分布差异也无显著性（χ2=0.049，P>0.05）。结论：TNF-308基因多态性与哮喘发病无关联。
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| 关 键 词： | 遗传学 肿瘤坏死因子 多态现象(遗传学) 疾病遗传易感性 |
| 文章编号： | 1671-587X(2005)03-0449-03 |
| 收稿时间： | 2004-06-11 |
| 修稿时间： | 2004年6月11日 |
Association between polymorphism of tumor necrosis factor promoter gene and asthma |
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| ZHAO Hai-Jun,DING Ya-chun,LIU Ya,SHI Jie-ping,LIU Hua-feng,ZHANG Jie,CHENG Huan-ji,CUI Yan-nan,HOU Song-ping.Association between polymorphism of tumor necrosis factor promoter gene and asthma[J].Journal of Jilin University: Med Ed,2005,31(3):449-451. |
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| Authors: | ZHAO Hai-Jun DING Ya-chun LIU Ya SHI Jie-ping LIU Hua-feng ZHANG Jie CHENG Huan-ji CUI Yan-nan HOU Song-ping |
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| Institution: | 1. Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, Changchun 130021,China;2. Department of Epidemiology, School of Public Health, Jilin University, Changchun 130021,China;3. Department of Respiratory Diseases, Second Hospital, Jilin University, Changchun 130041,China; 4. Department of Pediatrics, First Hospital, Jilin University, Changchun 130021,China |
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| Abstract: | Objective To detect the association between the polymorphism of tumor necrosis factor promoter gene (TNF-308) and asthma. Methods The technique of polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) was used to examine the allele frequencies of TNF-308 in 50 asthma patients and 80 normal controls. Results The allele frequency of TNF-308 gene was not significantly different between asthma group and normal control group (χ 2=0.047, P>0.05). Meanwhile, the frequencies of three genotypes (GG,GA and AA)of TNF-308 gene were not significantly different in asthma group (45/50, 5/50 and 0/50) and normal control group (71/80, 9/80 and 0/90)(χ 2=0.049,P>0.05). Conclusion There is not association between the polymorphism of tumor necrosis factor promoter gene (TNF-308) and asthma. |
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| Keywords: | asthma/genetics tumor necrosis factor polymorphism (genetics) genetic predisposition to disease |
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