丁苯酞治疗急性脑梗死的临床研究

目的比较奥扎格雷钠注射液和丁苯酞氯化钠注射液治疗急性脑梗死的临床疗效。方法选取2013年4月—2016年1月襄阳市中心医院住院治疗的80例急性脑梗死患者,采用随机数字表法将患者分为对照组和治疗组,每组各40例。对照组静脉滴注奥扎格雷钠注射液,80 mg稀释于500 m L生理盐水中,2次/d。治疗组静脉滴注丁苯酞氯化钠注射液,25 mg/次,2次/d。两组均连续使用14 d。观察两组的临床疗效,比较治疗前后两组的美国国立卫生院卒中量表(NIHSS)评分、血管内皮生长因子(VEGF)水平及脑血管储备能力。结果治疗后,对照组和治疗组的总有效率分别为75.00%、87.50%,两组总有效率比较差异有统计学意义(P0.05)。治疗7、14 d后,两组患者NIHSS评分明显降低,同组治疗前后比较差异具有统计学意义(P0.05);且治疗组NIHSS评分的降低程度明显低于同期对照组,两组比较差异具有统计学意义(P0.05)。治疗7、14 d后,两组患者VEGF水平明显升高,同组治疗前后比较差异具有统计学意义(P0.05);且治疗组VEGF水平呈先上升后下降的趋势,但明显高于同期对照组,两组比较差异具有统计学意义(P0.05)。治疗7、14 d后,两组患者脑血管储备能力明显升高,同组治疗前后差异具有统计学意义(P0.05)。且治疗组脑血管储备能力呈一直上升趋势,明显优于同期对照组,两组比较差异具有统计学意义(P0.05)。结论与奥扎格雷钠注射液比较,丁苯酞氯化钠注射液治疗急性脑梗死具有较好的临床疗效,能有效地恢复患者神经功能,提高VEGF水平,增加患者脑血管储备能力,值得临床推广应用。

Clinical study on butylphthalide in treatment of acute cerebral infarction

Objective To compare the effects of Butylphthalide and Sodium Chloride Injection and Sodium Ozagrel Injection in treatment of acute cerebral infarction. Methods Patients (80 cases) with acute cerebral infarction in Xiangyang Central Hospital from April 2013 to January 2016 were randomly divided into the control and treatment groups, and each group had 40 cases. The patients in the control group were iv administered with Sodium Ozagrel Injection, 80 mg added into 500 mL normal saline, twice daily. The patients in the treatment group were iv administered with Butylphthalide and Sodium Chloride Injection, 25 mg/time, twice daily. After treatment, the clinical efficacies were evaluated, and the changes of NIHSS scores, levels of VEGF, and cerebrovascular reserve capacity in two groups before and after treatment were compared. Results After treatment, the total efficacies in the control and treatment groups were 75.00% and 87.50%, respectively, and there were differences between two groups (P<0.05). After treatment for 7 and 14 d, NIHSS scores in two groups were significantly decreased, but level of VEGF and cerebrovascular reserve capacity were significantly increased, the differences were statistically significant in the same group (P<0.05). After treatment, the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusion Compared with Sodium Ozagrel Injection, Butylphthalide and Sodium Chloride Injection has clinical curative effect in treatment of acute cerebral infarction, can effectively improve the recovery of neurological function, the level of VEGF, and increased cerebral vascular reserve capacity in patients, which has a certain clinical application value.