| DNA去甲基化药物作用机制的研究进展 |
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| 引用本文： | 许嵘,张文州,陈琳琳,丁小明,谢志新,林阳君,辛军. DNA去甲基化药物作用机制的研究进展[J]. 现代药物与临床, 2017, 32(1): 152-157. DOI: 10.7501/j.issn.1674-5515.2017.01.035 |
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| 作者姓名： | 许嵘 张文州 陈琳琳 丁小明 谢志新 林阳君 辛军 |
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| 作者单位： | 1. 泉州医学高等专科学校 药学院，福建 泉州 362011; 南加州大学 凯克医学中心 诺里斯综合癌症中心，美国 洛杉矶 90089;2. 泉州医学高等专科学校 药学院,福建 泉州,362011;3. 福建医科大学附属泉州第一医院 泌尿外科,福建 泉州,362000 |
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| 基金项目： | 骨干院校建设重点科研项目（XJ1305）；福建省中青年教师教育科研项目（JAT160852）；泉州市科技计划项目（2013Z52） |
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| 摘 要： | 癌症被认为是一种表观遗传疾病。表观遗传异常改变导致参与细胞正常生长的关键基因失活,促进癌症发生和发展,这使得对癌症治疗上可采取一些主动性表观遗传调节。DNA去甲基化药物通过化学逆转重新激活高甲基化的肿瘤抑制基因,已成为一个令人兴奋的癌症治疗方法。其作用机制主要有:抑制DNA甲基转移酶,干扰甲基转移反应途径和影响三羧酸循环途径。介绍了近年来DNA去甲基化药物作用机制的研究进展。
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| 关 键 词： | DNA甲基化 DNA去甲基化药物 作用机制 癌症 |
| 收稿时间： | 2016-10-31 |
Research progress on action mechanism of DNA demethylating agents |
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| XU Rong,ZHANG Wen-zhou,CHEN Lin-lin,DING Xiao-ming,XIE Zhi-xin,LIN Yang-jun and XIN Jun. Research progress on action mechanism of DNA demethylating agents[J]. Drugs & Clinic, 2017, 32(1): 152-157. DOI: 10.7501/j.issn.1674-5515.2017.01.035 |
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| Authors: | XU Rong ZHANG Wen-zhou CHEN Lin-lin DING Xiao-ming XIE Zhi-xin LIN Yang-jun XIN Jun |
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| Affiliation: | School of Pharmacy, Quanzhou Medical College, Quanzhou 362011, China;Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles 90089, USA;School of Pharmacy, Quanzhou Medical College, Quanzhou 362011, China;School of Pharmacy, Quanzhou Medical College, Quanzhou 362011, China;School of Pharmacy, Quanzhou Medical College, Quanzhou 362011, China;School of Pharmacy, Quanzhou Medical College, Quanzhou 362011, China;School of Pharmacy, Quanzhou Medical College, Quanzhou 362011, China;Department of Urology, the First Hospital of Quanzhou Affiliated Fujian Medical University, Quanzhou 362000, China |
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| Abstract: | Cancer was regarded as an epigenetic disease in recent years. Aberrant epigenetic changes which lead to inactivation of pivotal genes were involved in correct cell growth, contributing to cancer development and progression, which had resulted in several initiatives implementing epigenetics in cancer treatment. DNA demethylating agents reactivating hypermethylated tumor suppressor genes, which caused chemical reversal of them, had become an exciting approach for cancer treatment. Three aspects of action mechanism mainly include:the inhibition of DNA methyltransferase, interference of the methyl transfer reaction pathway, and the influence of the tricarboxylic acid cycle. In this review, recent advances in the research of DNA demethylating agents are described according to their mechanism of action. |
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| Keywords: | DNA methylation DNA demethylating agents action mechanism cancer |
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