二十五味珊瑚丸联合卡马西平治疗癫痫的临床研究

目的探讨二十五味珊瑚丸联合卡马西平治疗癫痫的临床疗效。方法选取2015年4月—2016年4月在海南省第二人民医院接受治疗的癫痫患者82例,根据治疗方案的差别分为对照组(41例)和治疗组(41例)。对照组口服卡马西平片,起始剂量0.2 g/次,2次/d,连续治疗1周后调整剂量,每周增加0.1 g,至0.4 g/次,2次/d。治疗组在对照组的基础上口服二十五味珊瑚丸,1丸/次,1次/d。两组患者均连续治疗两个月。治疗后,观察两组的临床疗效,并比较两组治疗前后HAD、Mo CA评分,癫痫发作次数和癫痫积分,血清学指标及其不良反应的变化。结果治疗后,对照组和治疗组的总有效率分别为80.95%、95.24%,两组比较差异具有统计学意义(P0.05)。两组HAD评分显著降低,Mo CA显著升高,同组治疗前后比较差异具有统计学意义(P0.05);且治疗组上述评分比对照组改善的更明显(P0.05)。两组患者癫痫发作次数显著少于同组治疗前,癫痫积分显著低于同组治疗前(P0.05);且治疗组上述指标的改善程度优于对照组(P0.05)。两组患者血清IL-2、TNF-α水平均明显降低,同组治疗前后比较差异具有统计学意义(P0.05);且治疗组上述指标的降低程度优于对照组,两组比较差异具有统计学意义(P0.05)。两组在不良反应发生情况上比较差异无统计学意义。结论二十五味珊瑚丸联合卡马西平治疗癫痫临床效果显著,有利于患者认知功能的恢复及改善焦虑、抑郁状态,可明显减少癫痫发作次数和降低血清IL-2、TNF-α水平,具有一定的临床推广应用价值。

Clinical study on Twenty-five Ingredient Coral Pill combined with carbamazepine in treatment of epilepsy

Objective To investigate the clinical effects of Twenty-five Ingredient Coral Pill combined with carbamazepine in treatment of epilepsy. Methods Patients (82 cases) with epilepsy in the Second People’s Hospital of Hainan province from April 2015 to April 2016 were divided into control group (41 cases) and treatment group (41 cases) according to the different treatments. Patients in the control group were po administered with Carbamazepine Tablets, and the starting dose was 0.2 g/time, twice daily. After treatment for 1 week, the dose was increased 0.1 g/week until to 0.4 g/time, twice daily. Patients in the treatment group were po administered with Twenty-five Ingredient Coral Pill on the basis of the control group, 1 pill/time, once daily. The patients in two groups were treated for 2 months. After treatment, the clinical efficacies were evaluated, HAD and MoCA scores, number and integration of epilepsy, serological indexes, and adverse reactions before and after treatment in two groups were compared. Results The total efficacies in the control and treatment groups were 80.95%and 95.24%, respectively, and there were differences between two groups (P<0.05). HAD scores were significantly decreased, and MoCA scores were significantly increased, and the difference was statistically significant in the same group (P<0.05). And these scores in the treatment group were improved more significantly than those in the control group (P < 0.05). The number and integration of epilepsy were lower than those before treatment (P < 0.05). And the decreasing degree in the treatment group was obviously better than that in the control group, with significant difference between two groups (P<0.05). IL-2 and TNF-αlevels in two groups were significantly decreased (P<0.05). And the decreasing degree in the treatment group was obviously better than that in the control group, and there were significant differences between two groups (P<0.05). There was no significant difference in adverse reactions between two groups. Conclusion Twenty-five Ingredient Coral Pill combined with Carbamazepine Tablets has clinical curative effect in treatment of epilepsy, can restore the cognitive function and improve anxiety and depression, and significantly reduce seizure frequency and serum TNF-αand IL-2 levels, which has a certain clinical application value.