伐地那非对肾阳虚、肾阴虚及肝气郁结型勃起功能障碍的疗效分析

目的:观察伐地那非对肾阳虚、肾阴虚及肝气郁结型勃起功能障碍(ED)的临床疗效。方法:将124例ED患者按中医辨证分为肾阳虚型ED(44例)、肾阴虚型ED(41例)、肝气郁结型ED(39例),所有患者每天服用伐地那非5 mg,总疗程为8周。结果:伐地那非能显著提高各型ED患者的勃起功能问卷-5(IIEF-5)和勃起质量表(EQS)评分,且各组间比较差别有统计学意义(P<0.01);伐地那非显著提高肾阳虚和肾阴虚型ED患者性交成功百分率(P<0.01),肝气郁结型ED在治疗后性交成功百分率也有明显提高(P<0.05);伐地那非还能显著提高各型ED患者阴茎勃起硬度,3组治疗后总体有效率分别为81.82%、73.17%、43.59%。结论:伐地那非对肾阳虚和肾阴虚型ED患者疗效优于肝气郁结型ED患者。

Clinical efficacy of vardenafil on ED patients with kidney-yang or-yin deficiency or liver-qi stasis

Objective:To study the clinical efficacy of vardenafil on erectile dysfunction(ED) patients with kidney-yang deficiency,kidney-yin deficiency or liver-qi stasis.Methods:Based on the syndromes of Traditional Chinese Medicine,124 ED patients were divided into Groups A(kidney-yang deficiency,n=44),B(kidney-yin deficiency,n=41) and C(liver-qi stasis,n=39).All the patients were treated with vardenafil at 5 mg daily for 8 weeks,and the therapeutic effects were evaluated by comparing the scores on IIEF-5 and Erection Quality Scale(EQS) before and after the treatment.Results:After vardenafil treatment,the IIEF-5 and EQS scores of the ED patients were markedly increased,with statistically significant differences among the three groups(P < 0.01).The success rate of sexual intercourse was significantly improved in Groups A,B(P < 0.01) and C(P < 0.05).And the hardness of penile erection was enhanced by 81.82%,73.17% and 43.59% respectively in the three groups of patients.Conclusion:Vardenafil is more effective for ED patients with kidney-yang or kidney-yin deficiency than for those with liver-qi stasis.Natl J Androl,2010,16(9):856-859