促性腺素释放素拮抗剂在体外受精-胚胎移植中的LH峰抑制

目的:探讨促性腺素释放素拮抗剂(GnRHA)在体外受精-胚胎移植(IVF-ET)中应用的效果。方法:回顾性分析使用GnRHA方案的306个IVF-ET周期(实验组)和使用常规促性腺素释放素激动剂(GnRHa)长方案266个IVF-ET周期(对照组)。结果:实验组Gn用量少于对照组,但无显著性差异;GnRHA用药时间明显少于GnRHa;实验组平均获卵数、中、重度OHSS发生率明显低于对照组;优质胚胎移植率明显高于对照组。而二组受精率、卵裂率、优质胚胎移植率、胚胎冷冻率、种植率、妊娠率均无统计学差异。二组均无LH峰提早出现。结论:GnRHA为我们提供了一种安全的控制性超排卵方案,并可有效抑制LH峰过早出现。

Restraint of LH Apex by Gonadotropin Releasing Hormone Antagonist in IVF-ET

Objective: To evaluate the efficacy of gonadotropin releasing hormone antagonist (GnRHA) in IVF-ET. Methods: Patients were divided into two groups: experimental group, 306 cycles using GnRHA for controlled ovarian hyperstimulation (COH); control group, 266 cycles using GnRH analogue (GnRHa) for COH. Results: The dosage of Gn in experimental group was lower than that in the control, but there was no significant difference. The duration of treatment in experimental group was significantly shorter than that in the control, the average amount of oocyte retrieved and the incident rate of OHSS in experimental group were significantly less than those in the control, the high quality embryos transfer rate of experimental group was significantly higher than that in the control (P<0.05). Otherwise there were no statistical differences in the fertilization rate, the cleavage rate, the high-quality embryos transfusion rate, the frozen embryos rate, the embryo implantation rate and the clinical pregnancy rate. There was no LH apex in the two groups. Conclusion: GnRHA has provided us with a safe protocol in COH. GnRHA can restrain LH apex efficaciously.