肾综合征出血热患者血、尿肽结合羟脯氨酸测定的临床意义

用紫外分光光度法测定了１５例正常人和３７例肾综合征出血热（ＨＦＲＳ）患者在不同病期血、尿肽结合羟脯氨酸（ＰＨＰ）的改变。３７例ＨＦＲＳ患者血ＰＨＰ均高于正常人（Ｐ＜０．００１）；尿ＰＨＰ排出量（μｍｏｌ／２４ｈ）在发热期、恢复期接近于正常人（Ｐ＞０．０５），在低血压休克期、少尿期均低于正常人（Ｐ＜０．００１），多尿期高于正常人（Ｐ＜０．０５）。低血压休克期和少尿期血ＰＨＰ与血尿素氮（ＢＵＮ）、肌酐（Ｓｃｒ）呈正相关（Ｐ＜０．００１），尿ＰＨＰ与血ＢＵＮ、Ｓｃｒ呈负相关（Ｐ＜０．００１）。结果提示血ＰＨＰ、尿ＰＨＰ可能是判断肾功能状态的新的敏感指标。

Clinical Significance of Peptide-Bound Hydroxyproline in Serum and Urine in Patients with Hemorrhagical Fever complicated by with Renal Syndrom

The peptide-bound hydroxyproline(PHP)in serum and urine of the 15 normal subjects and 37 patients with hemorrhagical fever with renal syndrome (HFRS) was detected by the ultraviolet spectrophotom etry.The results showed that the mean PHP in serum of the 37 patients with HFRS was higher than that of the normal subjects(P<0.001),the uretic PHP in 24 hours in febrile and convalescent stages was close to that of the normal persons (P>0.05);in hypotensive and oliguric stages,lower than that of the normal controls (P<0.001);in diuretic stage,higer than that of the normal subjects (P<0.05).The concentr ation of PHP in serum in hypotensive and oliguric stages was positively correlated to BUN and Scr in serum respectively while the PHP urine excretion was ncgatively correlated to BUN and Scr in serum respectively.These results suggest that the measurement of concentration of PHP in serum and urine might help to ascertain the status of renal function.