| 质子泵抑制剂与酸反跳 |
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| 引用本文： | 陈维娜,张小晋.质子泵抑制剂与酸反跳[J].世界华人消化杂志,2010(28). |
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| 作者姓名： | 陈维娜 张小晋 |
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| 作者单位： | 北京积水潭医院消化科北京大学医学部第四临床医学院; |
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| 摘 要： | 酸反跳(rebound acid hypersecretion)指停用抑酸药物后胃酸分泌增加超过治疗前水平.质子泵抑制剂(proton pump inhibitors,PPIs)作为一代抑酸药物,比H2受体阻滞剂(histamine-2receptor antagonists,H2RA)具有更强的抑酸效果,是治疗酸相关疾病的主要药物.目前研究已经证实,PPIs可致酸反跳发生.PPIs的酸反跳可以再次诱发酸相关症状出现,不仅增加医疗预算,也给PPIs治疗的终止带来问题.高胃泌素血症是导致酸反跳现象的重要机制.正确使用PPIs,严格掌握适应证,探讨在有效治疗酸相关疾病的同时减少酸反跳发生的措施.
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| 关 键 词： | 质子泵抑制剂 酸反跳 治疗 |
Proton pump inhibitors and rebound acid hypersecretion |
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| Wei-Na Chen,Xiao-Jin Zhang.Proton pump inhibitors and rebound acid hypersecretion[J].World Chinese Journal of Digestology,2010(28). |
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| Authors: | Wei-Na Chen Xiao-Jin Zhang |
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| Institution: | Wei-Na Chen,Xiao-Jin Zhang,Department of Gastroenterology,Beijing Jishuitan Hospital & the Fourth Medical College of Peking University,Beijing 100035,China |
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| Abstract: | Rebound acid hypersecretion is defined as an increase in gastric acid secretion above pretreatment levels after cessation of antisecretory therapy.Proton pump inhibitors (PPIs) have been proved to be more effective than histamine-2 receptor antagonists in suppressing intragastric acidity and have therefore become the main choice for management of acid-related complaints.Recent studies have shown that PPI therapy-elicited rebound acid hypersecretion could in turn induce acid-related symptoms.This makes it di... |
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| Keywords: | Proton pump inhibitors Rebound acid hypersecretion Treatment |
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