| microRNA-21在肝脏中的作用 |
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| 引用本文： | 张莹,郑素军,段钟平. microRNA-21在肝脏中的作用[J]. 世界华人消化杂志, 2010, 0(25) |
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| 作者姓名： | 张莹 郑素军 段钟平 |
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| 作者单位： | 首都医科大学附属北京佑安医院; |
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| 基金项目： | “艾滋病和病毒性肝炎等重大传染病防治”科技重大专项基金资助项目,No.2008ZX10002-005-3; 国家自然科学基金资助项目,No.30800979; 北京自然科学基金资助项目,No.7102085; 北京市科技新星基金资助项目,No.2007B055; 首都医科大学基础-临床科研合作基金资助项目,No.2007JL02;No.2010JL02~~ |
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| 摘 要： | microRNAs(miRNAs)是一类新发现的小RNAs,因其能调控细胞活动的每个方面,包括分化、生长、代谢、增殖、凋亡和病毒感染、肿瘤生成,已经成为目前研究的热点.最近已有明确的证据表明,miRNAs在肝脏含量丰富并且参与肝脏生理和病理的各个过程.microRNA-21是目前研究最多的miRNAs之一,参与多种肿瘤的发生和一些病理生理改变,但其在肝脏中的研究比较少.本文就mi-croRNA-21在肝再生、肝细胞代谢、肝脏免疫反应及其在肝癌、丙型肝炎等肝病中的作用作一综述.
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| 关 键 词： | microRNA-21 肝脏 microRNAs |
Functions of microRNA-21 in the liver |
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| Ying Zhang,Su-Jun Zheng,Zhong-Ping Duan,Beijing Youan Hospital,Capital Medical University,Beijing ,China. Functions of microRNA-21 in the liver[J]. World Chinese Journal of Digestology, 2010, 0(25) |
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| Authors: | Ying Zhang Su-Jun Zheng Zhong-Ping Duan Beijing Youan Hospital Capital Medical University Beijing China |
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| Affiliation: | Ying Zhang,Su-Jun Zheng,Zhong-Ping Duan,Beijing Youan Hospital,Capital Medical University,Beijing 100069,China |
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| Abstract: | microRNAs(miRNAs) are a class of newly discovered small RNAs that can regulate every aspect of cellular activity,including differentiation,growth,metabolism,proliferation,apoptosis,viral infection,and tumorigenesis.Recent studies have provided clear evidence that miRNAs are abundant in the liver and participate in all physiological and pathological processes.microRNA-21(miR-21) is one of the most studied miRNAs and has been demonstrated to be involved in tumorigenesis and some pathophysiological changes.How... |
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| Keywords: | microRNA-21 Liver microRNA |
| 本文献已被 CNKI 等数据库收录！ |
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