大剂量红细胞生成素治疗尿毒症贫血的临床疗效观察

目的：观察大剂量红细胞生成素治疗尿毒症贫血的临床疗效。方法：收集36例行维持性血透治疗的慢性肾功能不全，尿毒症期病人随机分成两组，试验组18例，使用重组人红细胞生成素(rHu-EPO)10000U皮下注射每周1次，对照组18例，使用rHu-EPO3000U，皮下注射每周2次。治疗期间每次血透前检查血压，每周检查1次血常规，每2周检查1次肾功能，血电解质，肝功能，血糖，血胆固醇和甘油三酯。结果：试验组和对照组总有效率分别为94．45％，94．44％，疗效相似，除少数病人血压升高外，其他无明显副作用。结论：每周1次皮下注射10000U重组人红细胞生成素治疗尿毒症贫血疗效确切且安全可靠，其疗效与使用3000UrHu-EPO每周二次相同，同时减少了病人的注射次数，提高了患者的依从性及生活质量。

The Clinical Observation of Treatment of Uremic Anemia with High Dose of Recombinant Human Erythropoietin

Objective:To observate the clinical effect of treatment of uremic anemia by high dose of recombinant human erythropoietin.Methods:All 36 patients with chronic renal failure on maintenance hemodialysis were devided into two groups at random. There were 18 patients in treatment group treated with 10 000 U of rHu-EPO by subcutaneous injection once a week. 18 patients in contrast group were treated with 3 000 U of rHu-EPO by subcutaneous injection twice a week. Routine blood test was determined once a week and liver function, kidney function, serum electrolyte, cholesterol and triglycerine etc were determined erery two weeks. Results: The total effective rate is 94.45% of the treatment group and 94.44% of the contrast group is and there were no significant side effects in these two groups except several patients with hypertension. Conclusion: The clinical effect of 10000u of rHu-EPO on uremic anemia patients by subcutaneous injection once a week is effective and safe, and the effect is the same to that of using 3 000 U of rHu-EPO on uremic anemia patients by subcutaneous injection twice a week. And the amount of injection of the treatment group is reduced. The patients' compliance and their quality of life were improved.