SPOP在肾细胞癌中的研究现状及展望

肾细胞癌是泌尿系统常见的肿瘤之-..占肾癌病例的90%.其中又以透明细胞亚型最为常见。由于肾细胞癌对常规抗癌治疗的反应较差.其在癌症初期即可出现转移。肾细胞癌的高度转移性决定了对其进行早期诊断的必要性和重要性。尽管临床对肾细胞癌已投人大量研究精力.但其机制仍不明确。最近有研究表明,斑点型POZ蛋白(SPOP)可以以癌症类型特异性的方式发挥生物学功能。本文基于最新研究结果综述了SPOP在肾细胞癌中的研究现状及展望。

Research status and prospect of SPOP in renal cell carcinoma

Renal cell carcinoma is one of the most common urinary tract cancers,accounting for 90%of renal cancer cases,and the elear cell renal cell carcinoma is its most common subtype.Because of poor response to conventional anti-cancer treatment,metastasis may oceur in the early stage of renal cell careinoma.The high degree of metastasis of renal cell carcinoma detemines the necessily and importance of early diagnosis.Although a lot of researches about renal cell eareinoma have been carried oul,its underly ing mechanisms still remain unclear.Recent studies have shown that spot-type POZ protein(SPOP)can perform biological functions in a cancer type-specifie way.Based on the latest findings,this article reviewed the current research status and prospectives of SPOP in renal canecer cels.