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| 人IFN-α对人外周血单个核细胞ADCC活性的调节 | |
| 引用本文： | 江顺麟,言穆琳,沈鼎鸿. 人IFN-α对人外周血单个核细胞ADCC活性的调节[J]. 现代免疫学, 1984, 0(4) |
| 作者姓名： | 江顺麟 言穆琳 沈鼎鸿 |
| 作者单位： | 上海第二医学院微生物学教研室(江顺麟，言穆琳)，上海第二医学院微生物学教研室(沈鼎鸿) |
| 摘 要： | 本文以鸡红细胞为靶细胞,采用~(51)Cr释放法,检测正常成年人外周血单个核细胞的ADCC活性,并研究干扰素对这一活性的调节作用。发现Namalva细胞干扰素对正常成年人ADCC 活性有明显促进作用,其促进幅度依赖于所用干扰素的剂量和处理时间,抗人 IFN-α可抑制该促进作用。人白细胞干扰素亦能明显促进正常人ADCC活性,而鼠干扰素对人 ADCC活性则无明显促进作用。 |
THE EFFECT OF IFN-α ON HUMAN PBMC-ADCC ACTIVITY IN VITRO |
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| Abstract: | The ADCC activity in normal adults was examined in 51Cr release assay using antibody-coated chick erythrocytes as target cells and human peripheral blood mononuclear cells (PBMC) as effector cells, and the effect of IFN-α on the PBMC-ADCC activity was studied. It was found that the Namalva cell IFN enhanced the PBMC-ADCO activity. The magnitude of the enhancement was associated with the amount of IFN and the length of treatment. The anti-HuIFN- antiserum depressed the enhancement. Human leukocyte IFN had the same enhanced effect as Namalva cell IFN, while mouse IFN showed less affect. |
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