Occurrence of extended-spectrum β-lactamase-producing Salmonella enterica in northern Spain with evidence of CTX-M-9 clonal spread among animals and humans |
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| Authors: | I. Riañ o,M. Garcí a-Campello,Y. Sá enz,P. Á lvarez,L. Vinué ,M. Lantero,M. Á . Moreno,M. Zarazaga, C. Torres |
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| Affiliation: | Área de Bioquímica y Biología Molecular, Universidad de La Rioja, Logroño;, Servicio de Microbiología, Complejo Hospitalario de Pontevedra, Galicia;, Servicio de Microbiología, Hospital Universitario Central de Asturias, Oviedo;and Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad Complutense de Madrid, Madrid, Spain |
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| Abstract: | Among the 1233 Salmonella enterica isolates obtained in two Spanish hospitals, five isolates (0.4%) (serovars: Virchow, four; Livingstone, one) had the phenotype of an extended-spectrum β-lactamase (ESBL) producer. The genetic characterization of the ESBL of S. enterica Livingstone revealed a bla SHV-2 gene. The bla CTX-M-10 gene in a phage-related genetic environment was found in one S. enterica Virchow isolate, and the bla CTX-M-9 gene within the In60 integron was found in the three remaining Virchow isolates. These three isolates presented indistinguishable or closely related pulsed-field gel electrophoresis patterns among themselves and also as compared with the two other bla CTX-M-9-containing isolates previously obtained from animals. ESBL production is an emerging mechanism of resistance in S. enterica in the two studied hospitals. |
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| Keywords: | CTX-M-9 CTX-M-10 Salmonella enterica SHV-2 |
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