Clinical and genetic features of nonsyndromic autosomal dominant sensorineural hearing loss: KCNQ4 is a gene responsible in Japanese |
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| Authors: | J. Akita S. Abe H. Shinkawa W. J. Kimberling S. Usami |
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| Affiliation: | (1) Department of Otorhinolaryngology, Hirosaki University School of Medicine, Hirosaki, Japan, JP;(2) Department of Genetics, Boys Town National Research Hospital, Omaha, NE, USA, US;(3) Department of Otorhinolaryngology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan Tel. +81-263-37-2666; Fax +81-263-36-9164 e-mail: usami@hsp.md.shinshu-u.ac.jp, JP |
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| Abstract: | Sixteen Japanese nonsyndromic autosomal dominant sensorineural hearing loss (ADSNHL) families were investigated clinically as well as genetically. Most families showed postlingual hearing loss. Although the severity of their hearing loss varied, most patients showed mild-moderate sensorineural hearing loss of a progressive nature. Mutation analysis was performed for the MYO7A, KCNQ4, and GJB3 genes, which are known to be responsible for autosomal dominant sensorineural hearing loss. The present study reports that a mutation in KCNQ4, a member of a large family of potassium channel genes, was responsible for ADSNHL in one Japanese family. Received: January 16, 2001 / Accepted: March 15, 2001 |
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| Keywords: | Autosomal dominant Nonsyndromic hearing loss MYO7A KCNQ4 GJB3 |
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