急性期深静脉血栓形成妊娠女性炎症因子的表达及临床意义

目的探索急性期深静脉血栓形成（DVT）孕妇炎症因子的表达规律，分析孕妇DVT急性期炎症因子的表达水平与血栓演变的关联性。方法选取DVT孕妇（DVT组）、体检正常的孕妇（对照1组）和非妊娠的健康体检者（对照2组）各52例作为研究对象，检测对照1组、对照2组就诊时和DVT组孕妇T0、T1、T2、T3、T4五个时间段的凝血四项、超敏C-反应蛋白（hs—CRP）、肿瘤坏死因子（TNF）-α、白介素（IL）-6、IL-8、IL-10等指标，数据用EMPS软件做统计分析。结果与两个对照组比较，DVT组Tn的hs．CRP、TNF．d、IL-6、IL-8、IL-10等指标水平均明显增高（P均〈0．01），PT、TT、APTT降低（P均〈0．05），FIB升高（P〈0．05），差异均有统计学意义；DVT组T1的hs—CRP、TNF—α、IL-6、IL-8的水平均明显高于T0、T2、T3、T4的水平（P均〈0．01），T2的IL-10水平高于T0、T1、T3、T4的水平（P均〈0．01）。结论炎症因子的表达与孕妇DVT急性期病程走向密切相关，其水平呈现前高后低的规律变化，可作为DVT风险评估和干预的有效指标。

Expression of inflammatory factors and its clinical significance in pregnant women with acute deep veinthrombosis

Objective To investigate the regularity of inflammatory factors expression in pregnant women with acute deep vein thrombosis （DVT） and analyze the correlations between inflammatory factors expression levels and DVT development. Methods DVT pregnant women （ DVT group, n = 52 ）, pregnant women whose physical examination was normal （ control group 1, n = 52 ） and non-pregnant healthy subjects （ control group 2, n = 52 ） were enrolled in this study. Blood clotting panel （four coagulation tests including PT, APTT, TT and FIB）, high sensitivity C-reactive protein （hs-CRP） ,tumor necrosis factor（TNF） -α,interleukin （IL） -6 , IL-8, IL-10 at the time points TO （the first day）,T1 （the second day）,T2 （the third day）,T3 （the fifth day）and T4 （the seventh day）. In all participants were respectively detected. EMPS software was used for statistical analysis. Results Compared with control group 1 and 2, the levels of hs-CRP,TNF-α, IL -6, IL-8, IL-10 （ all P 〈 0.01 ） as while as FIB （ P 〈 0.05 ） increased significantly, and the levels of PT, TI＇, ATT decreased significantly （ all P 〈 0.05 ） in DVT group. In DVT group, the levels of hs-CRP,TNF-α, IL -6, IL-8 at T1 were significantly higher than those at To, T2, T3, T4, and the level of IL-10 at T2 was significantly higher than that at T0,T1 ,T3 and T4 （ all P 〈 0.01 ）. Conclusions There is a closed relation between the expression of inflammatory factors and the outcome of acute DVT course. The levels of inflammatory factors in acute stage DVT present early-stage high and late-stage low, and this may serve as effective indicator for risk assessment and intervention.