伴有软骨基质分泌的乳腺化生性癌临床病理学观察 |
| |
引用本文: | 田延龙,;吴宏培,;郝小康,;张冠军,;王一理. 伴有软骨基质分泌的乳腺化生性癌临床病理学观察[J]. 中国妇幼健康研究, 2014, 0(4): 598-599 |
| |
作者姓名: | 田延龙, 吴宏培, 郝小康, 张冠军, 王一理 |
| |
作者单位: | [1]西安交通大学医学部第一附属医院病理科,陕西西安710061; [2]陕西核工业215医院病理科,陕西咸阳712000; [3]西安交通大学医学部癌症研究所,陕西西安710061 |
| |
摘 要: | 目的分析伴有软骨基质分泌的乳腺化生性癌的临床病理学特征、免疫组化标记特点及其组织起源。方法收集5例伴软骨基质分泌的乳腺化生性癌的临床及随访资料,观察组织病理形态学及免疫组化标记,并对相关文献进行复习。结果5例患者年龄37~48岁,组织标本切面灰黄或灰褐色,结节状,界限尚清。镜下见肿瘤细胞围绕软骨粘液样或透明软骨样基质呈巢状,条索状排列,密集的瘤细胞可聚集于周边,中央区细胞稀疏,周边肿瘤细胞向基质移行中无梭形细胞肉瘤样成份。免疫组化结果显示,5例均同时表达CK、Vim及S-100,但不表达ER、PR、Her-2。结论伴有软骨基质分化的乳腺化生性癌是一种罕见肿瘤,具有特征性的病理组织形态和免疫表型,临床过程与普通非特异性浸润性乳腺癌无异。
|
关 键 词: | 乳腺化生性癌 基质分泌性癌 乳腺癌 病理学 |
Clinical pathology observation of matrix-producing metaplastic carcinoma of breast |
| |
Affiliation: | TIAN Yan-long , WU Hong-pei, HAO Xiao-kang, ZHAGN Guan-jun, WANG Yi-li ( 1. Department of Pathology, First Affiliated Hospital of Health Science Center, Xi ' an Jiaotong University, Shaanxi Xi ' an 710061, China; 2. Department of Pathology, The 215 Hospital of Shaanxi Nuclear Industry, Shaanxi Xianyang 712000, China; 3. Institute for Cancer Research, Health Science Center of Xi' an Jiaotong University, Shaanxi Xi' an 710061, China) |
| |
Abstract: | Objective To analyze the elinicopathological and immunohistochemical phenotypic features and origions of breast matrix- producing metaplastic carcinoma (MPC). Methods Clinical and follow-up data of 5 patients with MPC were collected. The histopathology was observed with H&E staining under light microscopy, and immunohistochemical staining was carried out for the immunophenotype evaluation. The related literatures were reviewed. Results The age of 5 patients ranged from 37 to 48 year. The neoplasms were nodular, and the cut surfaces were yellow or brown in color. Histopathologically, the tumors showed a well-circumscribed, nodular lesion composed of peripheral collections of tumor ceils arranged in nests and/or cords extending into a central area of cartilage or hyaline cartilage-like matrix. No intervening spindle cell component was present between the carcinoma and the matrix material. Metaplastic carcinoma cells merged from cellular periphery of tumor to matrix-rich central portion. Immunohistochemically, 5 cases were positive of CK, Vim and S- 100 but negative of ER, PR and Her-2. Conclusion MPC of breast cancer is an extremely rare variant of metaplastic carcinoma. MPC has featured pathohistological morphology and immunophenotypes and similar clinical characteristics with general non-specific breast cancer. |
| |
Keywords: | matrix-producing metaplastic carcinoma (MPC) matrix-producing carcinoma breast carcinoma pathology |
本文献已被 维普 等数据库收录! |
|