肿瘤干细胞在卵巢癌治疗中的进展

卵巢恶性肿瘤是死亡率最高的妇科恶性肿瘤。尽管标准化的治疗方法（包括理想的肿瘤细胞减灭术和以铂类／紫杉醇为基础的化疗方案）使得70％的患者得到一定程度的临床缓解，但绝大多数患者仍然会在2年内复发并出现耐药。肿瘤干细胞理论认为，肿瘤组织中有小部分细胞群体具有极强的增殖能力，它们具有类似正常干细胞的生物学特性，能通过自我更新和分化来高频度地启动肿瘤的发生发展，它们是导致肿瘤发生、发展、转移和耐药的主要细胞，是肿瘤复发的根源。该文将概述近几年卵巢癌干细胞的各项研究，包括卵巢癌干细胞的分离及其耐药机制、各种治疗方法等。

Progress of cancer stem cells in the treatment of ovarian cancer

Ovarian cancer is a gynecological malignant tumor with highest mortality. Although the standard treatment （including cytoreductive surgery and platinum/paclitaxel-based chemotherapy） has made 70% of ovarian cancer patients relieve, most of the patients relapse within two years and have drug resistance. The cancer stem cells （CSCs） theory explains that there is a small subgroup of tumor cells with strong ability to proliferate, They have similar biological capacities to normal stem cells, which can frequently initiate tumor regeneration and progress through self-renew. They are the major ceils promoting tumor regeneration, progress, invasion and chemoresistance, and they are the primary cause of tumor recurrence. This article summarized different investigations on ovarian CSCs, including isolation, mechanisms of chemoresistance and therapeutic approaches.