Influence of antidepressants on intracellular levels of cyclic adenosine monophosphate in human peripheral blood mononuclear cells. |
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| Authors: | Gunter Kenis Harry Steinbusch Marc De Baets Michael Maes |
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| Affiliation: | Department of Psychiatry and Neuropsychology, University of Maastricht, P.O. Box 616, 6200 MD Maastricht, The Netherlands. g.kenis@np.unimaas.nl |
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| Abstract: | This study examines the effects of paroxetine and imipramine on intracellular concentrations of cyclic adenosine monophosphate (cAMP) in human peripheral blood mononuclear cells. It was found that imipramine and paroxetine had no effect on basal cAMP-levels. Stimulation with lipopolysaccharides and phytohaemagglutinin increased intracellular cAMP concentrations. However, pre-incubation with imipramine or paroxetine, did not influence this increase. These data do not support the hypothesis that cAMP may be related to the in vitro anti-inflammatory effects of antidepressants. |
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