| b-FGF在肾癌组织中表达的临床意义 |
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| 引用本文： | 车乐,朱积川,姜辉. b-FGF在肾癌组织中表达的临床意义[J]. 中华泌尿外科杂志, 2000, 21(10): 596-598 |
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| 作者姓名： | 车乐 朱积川 姜辉 |
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| 作者单位： | 北京军区总医院泌尿外科(车乐)，北京大学人民医院泌尿外科(朱积川!100044，姜辉!100044，李鹰!100044，王晓峰!100044，侯树坤!100044) |
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| 摘 要： | 目的 探讨ｂ－ＦＧＦ（碱性成纤维细胞生长因子）在肾癌中表达的临床意义。方法 采用斑点杂交技术和免疫组化技术测定２０例肾癌患者癌组织、癌旁和正常肾组织ｂ－ＦＧＦ表达情况。结果 肾癌组织中ｂ－ＦＧＦ表达明显高于癌旁和周围正常肾组织（Ｐ〈０．０１），ｂ－ＦＧＦ表达升高与肿瘤分期、分级密切相关，与肿瘤大小无明显关系。结论 ｂ－ＦＧＦ为肾癌组织自身分泌，与肾癌的发生和发展密切相关。
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| 关 键 词： | 肾癌 碱性成纤维细胞生长因子 免疫组织化学 |
Expression of b FGF in renal cell carcinoma |
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| CHE Le. Expression of b FGF in renal cell carcinoma[J]. Chinese Journal of Urology, 2000, 21(10): 596-598 |
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| Authors: | CHE Le |
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| Abstract: | Objective To investigate the clinical significance of b FGF in human renal carcinoma. Methods 20 cases of renal carcinoma were examined using RNA dot blot hybridization and immunohistochemical technique. Results b FGF expression was significantly higher in human renal cancer tissue than the normal human renal tissue and tissue surrounding the tumor. b FGF expression was of no statistic significance as to tumor size, but it was of statistic significance as to clinical stage or clinical grade. Conclusions b FGF is secreted from tumor tissue itself. b FGF is closely involved in the development and growth of renal cell carcinoma. |
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| Keywords: | Kidney neoplasms Carcinoma Immunohistochemical |
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