局部注射化疗药治疗胃癌的动物实验研究

以人胃癌细胞ＳＧＣ─７９０１接种于裸鼠大腿皮下复制裸鼠人胃癌模型，采用１３９─３在肿瘤局部注射给药，观察对肿瘤生长的抑制作用，同时与油酸多相脂质体，５─Ｆｕ及生理盐水作对照，结果表明：１３９─３局注的抗肿瘤效果明显优于１３９─１和５─Ｆｕ单独使用。组织学检查发现１３９─３局注除引起肿瘤细胞变性坏死外，局部还有巨噬细胞浸润，表明１３９─３局注增强了局部抗肿瘤免疫功能。本文采用１３９─３局注治疗，未发现动物有饮食，精神状态及皮肤改变，组织学检查未发现对正常组织有损伤。

ANIMAL EXPERIMENTAL STUDY ON INTRATUMOR INJECTION OF CHEMICAL DRUG FOR THE TREATMENT OF GASTRIC CANCER OF NUDE MICE

Human gastric cancer cell SGC-7901 was inoculated subcutaneously into the legs of nude mice to make out a model of nude mice bearing human gastric cancer.139-3 was injected intratumorly to observe its inhbitive effect of cancer growth.139-1,5-fluorouracil and normal saline were set as contrasts.The results suggest:The anticancer effect of intratumor injection of 139-3 is significanty better than that of 139-1 and 5-Fu.Its enhancement is caused by synergism of 139-1 and 5-Fu.Histologically,not only the tumor cells are degenerated and necrotic but there is phagocyic infiltration in the focus.This enforces the immune function of anticancer drug.Under the electronic microscope,mitochondrin is swollen and necrotic in 139-1 group.This confirms the anti-cancer effect of 139-1 after intratumor injection and supports the anti-cancer mechanism of unsaturated fatty acid with morphological evidence.Mice in this study did not show anorexia,psychiatric and skin abnormality.In the sections there is no damage to normal tissue.