Molecular modeling study and synthesis of novel dicationic flexible triaryl guanidines and imidamides as antiprotozoal agents |
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Authors: | Arafa Reem K Wenzler Tanja Brun Reto Chai Yun Wilson W David |
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Institution: | aDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Kasr El-Aini st., 11562, Cairo, Egypt;bSwiss Tropical and Public Health Institute, Basel CH4002, Switzerland;cUniversity of Basel, Basel CH-4002, Switzerland;dDepartment of Chemistry, Georgia State University, Atlanta, GA 30303-3083, USA |
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Abstract: | A new series of fourteen dicationic flexible triaryl bis-guanidines 3a,b, bis-N-substituted guanidines 7a,b and 8a,b as well as bis-imidamides 9–12a,b having a 1,3- or 1,4-diphenoxybenzene scaffold backbone were synthesized. The in vitro activity of the novel dications as antiprotozoal agents against Trypanosoma brucei rhodesiense (T.b.r.) and Plasmodium falciparum (P.f.) was assessed. Interestingly, six of the newly synthesized dications viz3a,b, 7a,b and 8a,b were more active against P.f. than the reference drug pentamidine. Also, some of the dications showed moderate antitrypanosomal activity. Thermal melting analysis of the novel dications was performed to determine their ligand-DNA relative binding affinities. Finally, docking of the dications with an AT rich DNA oligonucleotide was executed to understand their binding mode with the minor groove. |
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Keywords: | Dicationic flexible triaryl guanidines Dicationic flexible triaryl imidamides Antiprotozoal agents DNA minor groove binders Thermal melting analysis Molecular modeling and docking |
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