去白细胞全血输注在肾移植中的应用

目的　评价去白细胞全血输注法治疗肾移植前后高危贫血病人的临床价值。　方法　观察比较15例肾移植前（A组）和38例肾移植后（B组）病人输注去白细胞全血以及33例肾移植前随机输血病人（C组）的群体反应抗体水平（PRA）、急性排斥发生率和巨细胞病毒感染率及巨细胞病毒肺炎发生率。　结果　白细胞滤器的去白细胞效率为(98.2±1.5)%，输注去白细胞全血病人仅1例出现荨麻疹，A组输去白细胞全血后PRA阴性，肾移植术后无急性排斥发生，B组输血后无加重或发生排斥反应，C组术前PRA阳性率达100.0％，术后早期急性排斥率为29.0％，A组与C组术后巨细胞病毒感染率及巨细胞病毒肺炎发生率差别无显著性意义。　结论　肾移植前后严重贫血短期无法纠正时，输注去白细胞全血是安全的。

Transfusion of leukocyte-depleted blood in renal transplantation

Objective　To evaluate transfusing of leukoc yte-depleted blood to severe anemia patients before and after renal transplanta tion.　Methods　The efficiency of leukocyte removal filter was observed and the level of panel reactive antibody (PRA) compared.The acute rejection rate and the incidence of cytomegalovirus infection were studied in 5 3 leukocyte-depleted blood transfused patients and in 33 whole blood transfused patients.　Results　The leukocyte removal rate of the fil ter reached 98.2%±1.5%.In the leukocyte-depleted blood transfused patients,the re was no rise of PRA neither the occurrence of acute rejection.Whereas the inci dence of cytomegalovirus infection has been similar to those with whole blood tr ansfusion.The whole blood transfused patients had high PRA and the early acute r ejection rate reached 29.0%　Conclusions　The clinical app lication of leukocyte-depleted blood transfusion for severe anemia patients bef ore or after renal transfusion is safe and beneficial.