超敏C-反应蛋白的检测及其在冠心病中的应用

目的测定冠心病患者血清超敏C-反应蛋白(hs-CRP)水平,探讨其在冠心病的发病及病情监测中的作用.方法用全自动免疫散射比浊法检测35例急性心肌梗死(AMI)、29例不稳定性心绞痛(UA)、33例稳定性心绞痛(SA)、30例健康者血清hs-CRP水平结果AMI、UA、SA患者与正常对照组相比,hs-CRP水平明显升高,且3组间差异有显著性.结论血清hs-CRP水平可以作为冠心病的早期诊断指标并可作为监测病情的指标.

Clinical Significance of C-reactive Protein in Patients with Coronary Heart Disease

Objective:To evaluate the significance of hyper-sensitive C-reactive protein (CRP) in patients with coronary artery disease (CAD) by detecting serum concentration of CRP. Methods:The study groups included 35 cases of acute myocardial infarction (AMI) within 24 hours after the onset, 29 unstable angina (UA) within 24 hours after the last episode,33 stable angina (SA);and the control group of 30 healthy subjects. CRP level of each group was measured by untrasensitive immunoassay respectively. Results:The CRP levels in patients were higher than those in control group( P <0.001),and there were significanct differences among the three groups,comparing UA with SA, P <0.001 and comparing AMI with UA, P < 0.001 .Conclusion:Significant correlation was identified between CRP levels and severity of CAD. Increased CRP is an early prognostic indicator for patients with coronary artery disease, and it might be an available predictor for the severity of CAD.