A study on organic nitrates,Part VI. Synthesis and pharmacological activity of 1-isopropylamino-3-(1-naphthyloxy)-2-propyl nitrate |
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| Authors: | Korzycka Lucyna Owczarek Jacek Czarnecka Elzbieta |
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| Affiliation: | Department of Pharmaceutical Chemistry and Drug Analysis, Medical University, 1 Muszyńskiego Str., 90-151 Lód?, Poland. |
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| Abstract: | ![]()
Basing on the studies on the relationship between the structure and activity, we have synthesized a nitrate analogue of propranolol as potential donor of nitric oxide. The obtained 1-isopropylamino-3-(1-naphthyloxy)-2-propyl nitrate decreases blood pressure more than propranolol and slows the heart rate less than propranolol. It also affects peripheral vascular resistance less than propranolol. |
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