既往血吸虫感染者体检数据分析及其与脂肪肝、冠心病的关系

目的了解既往血吸虫感染者的健康状况,并研究其与脂肪肝、冠心病的关系。方法在华东疗养院2016年6万余例体检人群中,筛选出既往血吸虫感染者272人为研究对象;采用计算机产生的随机数字以1∶100的比例,从同期体检人群中抽取277人为对照组。收集研究对象的详细病史、彩色多普勒超声和实验室检查结果。利用Logistic回归分析既往血吸虫感染与脂肪肝、冠心病等疾病的关系。结果既往血吸虫感染组中脂肪肝和冠心病患病人数分别为26例和5例,对照组相应为119例和14例,两组比较差异均有统计学意义(P<0.05);既往血吸虫感染组的TG、AIP、空腹血糖以及血小板分别为(1.28±0.67)mmol/L、(-0.08±0.27)、(5.82±1.19)mmol/L和(182.01±49.20)×109/L,均比对照组的(1.79±1.26)mmol/L、(0.11±0.30)、(6.09±1.63)mmol/L和(199.22±47.03)×109/L低,两组比较差异均有统计学意义(P<0.05);既往血吸虫感染组的HDL-C为(1.42±0.35)mmol/L1、总胆红素为(14.59±5.08)μmol/L,分别与对照组的(1.22±0.34)mmol/L和(13.26±4.38)μmol/L比较差异均有统计学意义(P<0.05)。结论既往血吸虫感染者高血压、糖尿病患病率与同年龄段人群相仿,但既往血吸虫感染可能与轻度脂肪肝、冠心病呈负相关。

Physical examination data of patients with previous schistosome infection and its relationship with hepatic adipose infiltration and coronary heart disease

Objective To find the health status of patients with previous schistosome infection, also to research the relationship between previous schistosome infection and hepatic adipose infiltration, coronary heart disease and other diseases. Methods Among the more than 60 000 people with physical examination in East China Sanatorium, 272 people with previous schistosome infection were selected for the study. Computer-generated random numbers were used to select 277 people from the physical examination personnel during the same period at a ratio of 1∶100 as the control group. The medical history, color Doppler ultrasound, and laboratory results of the study subjects were collected. The association of previous schistosome infection and hepatic adipose infiltration, coronary heart disease were analyzed with the logistic regression methods. Results There were 26 cases of fatty liver disease and 5 cases of coronary heart disease in the previous schistosome infection group, and 119 cases and 14 cases in the control group respectively (P<0.05). In the previous schistosome infection group, the TG, AIP, FBG and platelet levels were (1.28±0.67) mmol/L, (-0.08±0.27), (5.82±1.19) mmol/L and (182.01± 49.20) ×10⁹/L, lower than the control group (1.79±1.26) mmol/L, (0.11± 0.30), (6.09± 1.63) mmol/L, and (199.22± 47.03) ×10⁹/L (P<0.05). In previous schistosome infection group, HDL-C was (1.42±0.35)mmol/L, total bilirubin was (14.59±5.08) μmol/L, higher than the control group （1.22±0.34）mmol/L and （13.26±4.38）μmol/L (P<0.05). Conclusions The prevalence of hypertension and diabetes in the patients with previous schistosome infection was similar to those of the same age group. Previous schistosome infection was negatively correlated with mild hepatic adipose infiltration and coronary heart disease.