| 年龄相关性黄斑变性的发病机制与抗氧化治疗 |
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| 引用本文： | 孙子雯,汤垟,陈晨,胡竹林.年龄相关性黄斑变性的发病机制与抗氧化治疗[J].国际眼科杂志,2020,20(3):468-471. |
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| 作者姓名： | 孙子雯 汤垟 陈晨 胡竹林 |
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| 作者单位： | 昆明医科大学第四附属医院(云南省第二人民医院)眼科 云南省眼科研究所 云南省眼部疾病临床医学研究中心 云南省眼病临床医学中心 云南省眼科疾病防治研究重点实验室 云南省姚克专家工作站, 中国云南省昆明市,650021 |
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| 基金项目： | 国家自然科学基金委员会资助项目(No.81660167); 云南省科技计划项目(No.2017FB114); 云南省创新团队计划(No.2017HC010); 云南省重要眼表疾病预防和诊治新技术研究(No.2018ZF009) |
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| 摘 要： | 年龄相关性黄斑变性(ARMD)好发于50岁及以上中老年人,呈进行性发展,可导致单眼或双眼部分甚至完全性视力丧失。虽然目前其发病机制尚不明确,但已有数据表明氧化应激在ARMD的发病过程中起到了重要作用。近年来对ARMD抗氧化机制方面的研究逐渐成为研究热点,本文就氧化应激介导ARMD的发生机制以及ARMD抗氧化剂的应用作一简要综述。
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| 关 键 词： | 年龄相关性黄斑变性 衰老 氧化应激 抗氧化 色素 |
| 收稿时间： | 2019/8/27 0:00:00 |
| 修稿时间： | 2020/2/13 0:00:00 |
The pathogenesis and antioxidant treatment of age-related macular degeneration |
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| Zi-Wen Sun,Yang Tang,Chen Chen and Zhu-Lin Hu.The pathogenesis and antioxidant treatment of age-related macular degeneration[J].International Journal of Ophthalmology,2020,20(3):468-471. |
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| Authors: | Zi-Wen Sun Yang Tang Chen Chen and Zhu-Lin Hu |
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| Institution: | Department of Ophthalmology, Fourth Affiliated Hospital of Kunming Medical University(the Second People''s Hospital of Yunnan Province); Yunnan Eye Institute; the Ocular Disease and Clinical Medicine Research Center of Yunnan Province; the Ocular Disease Clinical Medicine Center of Yunnan Province; Key Laboratory of Yunnan Province for the Prevention and Treatment of Ophthalmology; Expert Workstation of Yao Ke, Kunming 650021, Yunnan Province, China,Department of Ophthalmology, Fourth Affiliated Hospital of Kunming Medical University(the Second People''s Hospital of Yunnan Province); Yunnan Eye Institute; the Ocular Disease and Clinical Medicine Research Center of Yunnan Province; the Ocular Disease Clinical Medicine Center of Yunnan Province; Key Laboratory of Yunnan Province for the Prevention and Treatment of Ophthalmology; Expert Workstation of Yao Ke, Kunming 650021, Yunnan Province, China,Department of Ophthalmology, Fourth Affiliated Hospital of Kunming Medical University(the Second People''s Hospital of Yunnan Province); Yunnan Eye Institute; the Ocular Disease and Clinical Medicine Research Center of Yunnan Province; the Ocular Disease Clinical Medicine Center of Yunnan Province; Key Laboratory of Yunnan Province for the Prevention and Treatment of Ophthalmology; Expert Workstation of Yao Ke, Kunming 650021, Yunnan Province, China and Department of Ophthalmology, Fourth Affiliated Hospital of Kunming Medical University(the Second People''s Hospital of Yunnan Province); Yunnan Eye Institute; the Ocular Disease and Clinical Medicine Research Center of Yunnan Province; the Ocular Disease Clinical Medicine Center of Yunnan Province; Key Laboratory of Yunnan Province for the Prevention and Treatment of Ophthalmology; Expert Workstation of Yao Ke, Kunming 650021, Yunnan Province, China |
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| Abstract: | Aged-related macular degeneration(ARMD)is prone to occur in the people who aged 50a or older. The disease can lead to partial or even complete loss of sight in single or both eyes progressively. The pathogenesis of ARMD is still unclear, but the previous studies have shown that oxidative stress plays an important role. The mechanism of antioxidants on ARMD has gradually become a hotspot in recent years. In this paper, we briefly reviewed the mechanism of ARMD caused by oxidative stress and the application of antioxidants on ARMD. |
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| Keywords: | age-related macular degeneration senility oxidative stress antioxidant pigment |
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