初治、复治肺结核患者细胞免疫功能与营养状况比较

目的 探讨初治、复治肺结核患者细胞免疫功能与营养状况。方法 选择2013年12月—2016年12月在河北省胸科医院进行治疗的200例肺结核患者的为研究对象,按照患者是否为初次治疗分为初治组和复治组,其中初治组117例,复治组83例,分析两组患者的细胞免疫和营养状况指标。结果 复治组患者的CD3⁺、 CD4⁺T细胞与CD4⁺ /CD8⁺数值分别为（64.15±9.12）%、（35.21±6.37）%、（1.13±0.09）%,均低于初治组（71.07±8.07）%、（43.28±7.96）%、（1.52±0.13）%,而CD8⁺T细胞计数复治组（36.36±7.58）%高于初治组（28.55±6.89）%,差异均具有统计学意义（P<0.05）;初治组患者的NK细胞、B淋巴细胞、IgG、IgA、IgM数值分别为（12.37±5.98）%、（12.41±7.74）%、（12.37±6.28） g/L、（2.13±0.26） g/L、（1.34±0.52） g/L,复治组为（11.89±6.38）%、（13.21±6.41）%、（13.35±7.24） g/L、（2.17±0.31） g/L、（91.42±0.45） g/L,两组比较差异均不具有统计学意义（P>0.05）;复治组BMI、血红蛋白、总淋巴细胞计数和白蛋白数值分别（18.64±3.68） kg/m²、（110.36±15.57） g/L、（1.63±0.52）×10⁹/L、（30.05±5.84） g/L,均低于初治组相应数值（20.34±3.58）kg/m²、（119.86±17.85） g/L、（1.92±0.61）×10⁹/L、（34.25±6.31） g/L,差异均具有统计学意义（P<0.05）。结论 初治与复治肺结核患者的细胞免疫功能指标在疾病的诊断、治疗和预后推断中有着重要意义,在进行临床诊断和治疗过程中,需要对此类指标进行监测。复治肺结核患者身体营养状况较差,需要在治疗过程中保证营养的摄入。

Cellular immune function and nutritional status in newly treated and retreated pulmonary tuberculosis patients

Objective To investigate the comparison of cellular immune function and nutritional status between newly treated and retreated patients with pulmonary tuberculosis. Methods A total of 200 pulmonary tuberculosis patients were selected in Hebei Province Chest Hospital from December 2013 to December 2016. According to whether for the first treatment, the patients were divided into the initial treatment group 117 patients and retreatment group 83 patients. Cellular immune and nutritional status indicators were analyzed of patients of the two groups. Results The level of CD3⁺T cells, CD4⁺T cells and CD4⁺ /CD8⁺ in the retreatment group （64.15±9.12）%,（35.21±6.37）%,（1.13±0.09）% were lower than those in the initial treatment group（71.07±8.07）%,（43.28±7.96）%,（1.52±0.13）%, and the level of CD8⁺T cells were higher than those of the initial treatment group （28.55±6.89）% (P<0.05). The level of NK cells, B lymphocytes, IgG, IgA and IgM in the initial treatment group （12.37±5.98）%,（12.41±7.74）%,（12.37±6.28） g/L,（2.13±0.26） g/L,（1.34±0.52）g/L and the retreatment group （11.89±6.38）%,（13.21±6.41）%,（13.35±7.24） g/L,（2.17±0.31） g/L,（91.42±0.45） g/L were not statistically significant (P>0.05). BMI, hemoglobin, total lymphocyte count and albumin in the retreatment group （18.64±3.68） kg/m²,（110.36±15.57） g/L,（1.63±0.52）×10⁹/L,（30.05±5.84） g/L were lower than those in the initial treatment group （20.34±3.58）kg/m²,（119.86±17.85） g/L,（1.92±0.61）×10⁹/L,（34.25±6.31） g/L (P<0.05). Conclusion The initial treatment and retreatment of pulmonary tuberculosis patients with cellular immune function index in diagnosis of diseases, plays an important role in the treatment and prognosis of inference, in the process of clinical diagnosis and treatment, monitoring of such indicators is required. The nutritional status of the patients with retreatment TB is poor, so it is necessary to ensure the nutrition intake during the treatment.