患宫颈病变的维、汉族妇女高危型HPV分型比较研究

目的探讨人高危型乳头瘤病毒（HPV）在维吾尔族宫颈炎,宫颈癌前病变,宫颈癌中的分布及意义。方法应用Hybrimax基因芯片导流杂交技术,对2011年11月至2012年10月在新疆维吾尔自治区人民医院就诊的HC2结果阳性的428位维吾尔族及汉族妇女的宫颈细胞标本进行HPV基因型分型检测。结果 HPV16型在维吾尔族及汉族妇女在慢性宫颈炎,宫颈癌前病变和宫颈癌等不同病变比较中,差异具有统计学意义（P〈0.05）,但是两民族间的分布差异无统计学意义（P〉0.05）。HPV感染在两个民族同样是以单一感染为主,其中HPV16型单一感染最多。除HPV16、18型外,维吾尔族妇女全部宫颈脱落细胞中（宫颈炎、癌前病变及宫颈癌）常见亚型检出次数依次为HPV52、53、58、39、68,31、66、56、6和11型。汉族妇女为HPV52、58、53、31、33、68、66、39、45、11、6和CP8304型。结论 HPV16型感染是维、汉妇女正常宫颈、癌前病变及宫颈癌中常见的型别,同时随着病变进展所占比例增加,两个民族间分布差异无统计学意义（P〉0.05）;除HPV16、18型以外,高危型HPV52、58型在维、汉妇女各级别病变中最多见。维、汉妇女宫颈各病变中HPV感染以单一感染为主,两个民族妇女癌前病变及宫颈癌以HPV16型单一感染为最多见。

HPV genotyping results in Uygur and Han women with different cervical lesions

Objective To investigate the distribution and significance of the HPV16 in chronic cervicitis, cervical intraepithelial neoplasia（CIN）and cervical carcinoma.Methods 428 patients with Hr HPV infection on cervix were tested for HPV genotypes by flow-through hybridization and gene chip（HybriMax）.Results Apart from HPV-16,18,the most common HPV types in Uighur women were HPV52,53,58,39,68,31,66,56,6 and 11.While in Han women they were HPV52,58,53,31,33,68,66,39,45,11,6and CP8304.Single infection was dominant in both Uighur and Han women,multiple infection was less.Conclusions HPV16 is the most common HPV type in chronic cervicitis,CIN and cervical carcinoma both in Uighur and Han.As the lesion progressed,HPV16constituent ratio also increased,but there was no difference between the Uighur and Han;Except the type HPV16 and HPV18,the high-risk type of HPV52,58were the most common types in the Uighur and Han women at all cervical lesions.