瑞舒伐他汀与考来烯胺治疗血脂异常的疗效观察

目的观察瑞舒伐他汀与考来烯胺治疗血脂异常的疗效及安全性。方法80例血脂异常患者随机分为瑞舒伐他汀组40例和考来烯胺组40例，治疗12周。分别测定治疗前后总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）等。结果治疗12周后瑞舒伐他汀组TC、LDL—C、TG水平与治疗前比较有明显降低，HDL—C升高，与治疗前比较差异有统计学意义（P〈0．05）。考来烯胺组TC、LDL—C下降，HDL—C增高，与治疗前比较差异有统计学意义（P〈0．05），TG无明显变化。结论瑞舒伐他汀和考来烯胺均可有效调脂。

Efficacy of rosuvastatin and cholestyramine on dyslipidemia

Objective To observe the safety and efficacy of rosuvastatin and cholestyramine in the treatment of dyslipidemia. Methods Eighty patients with dyslipidemia were randomly divided into rosuvastatin group（40 cases） and eholestyramine group （40 cases） , and the treatment course was 12 weeks. The levels of total cholesterol（TC） , triglyceride（TG） , high density lipo- protein cholesterol（HDL-C） , low density lipoprotein cholesterol（LDL-C） before and after the treatment were detected. Results After 12 weeks, the levels of TC, LDL-C and TG in rosuvastatin group were decreased signifieantly and the level of HDL-C in-creased, there were significant differences compared with those before treatment （ P 〈 0.05 ）. The levels of TC and LDL-C de-creased and the level of HDL-C increased in cholestyramine group, there were significant differences compared with those before treatment （ P 〈 0.05 ）. There was no significant difference in TG level. Conclusion Both of rosuvastatin and cholestyramine can regulate serum lipid effectively.