| 视黄醇结合蛋白4与胰岛素抵抗 |
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| 引用本文： | 吴海娅,贾伟平. 视黄醇结合蛋白4与胰岛素抵抗[J]. 国际内分泌代谢杂志, 2008, 28(5) |
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| 作者姓名： | 吴海娅 贾伟平 |
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| 作者单位： | 上海市糖尿病研究所,上海交通大学附属第六人民医院内分泌代谢科,上海市糖尿病临床医学中心,200233 |
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| 基金项目： | 国家自然科学基金，国家重点基础研究发展计划(973计划) |
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| 摘 要： | 脂肪组织是一个重要的内分泌器官.肥大的脂肪细胞分泌过量脂肪细胞因子,促进了胰岛素抵抗和糖尿病的发生、发展.视黄醇结合蛋白4(RBP4)主要由肝脏合成,负责维生素A的转运.新近研究发现,RBP4是一个新的脂肪细胞因子,与胰岛素抵抗相关疾病、体脂分布和糖尿病均有密切联系,它的发现为明确胰岛素抵抗发生机制提供了新的论据.
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| 关 键 词： | 视黄醇结合蛋白4 胰岛素抵抗 糖尿病 |
Retinol binding protein 4 and insulin resistance |
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| WU Hai-ya,JIA Wei-ping. Retinol binding protein 4 and insulin resistance[J]. International JOurnal of Endocrinology and Metabolism, 2008, 28(5) |
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| Authors: | WU Hai-ya JIA Wei-ping |
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| Abstract: | Adipose tissue is an important endocrine organ.Enlarged adipocytes produce excess adipocytokines,which promote the development of insulin resistance and diabetes.Retinol binding protein 4 (RBP4)is mainly produced by liver and plays an important role in transportation of vitamin A.Recent studies have shown that RBP4 is a new adipocytokine associated with insulin resistance related diseases,fat distribution,and diabetes.The discovery of RBP4 provides new evidents for illuminating the mechanism of insulin resistance. |
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| Keywords: | Retinol binding protein 4 Insulin resistance Diabetes mellitus |
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