| 吉西他滨单药治疗老年晚期非小细胞肺癌的疗效分析 |
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| 引用本文： | 姜宏宁,余敏. 吉西他滨单药治疗老年晚期非小细胞肺癌的疗效分析[J]. 临床肺科杂志, 2009, 14(2): 196-197 |
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| 作者姓名： | 姜宏宁 余敏 |
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| 作者单位： | 北京老年医院肿瘤科,100095;北京老年医院肿瘤科,100095 |
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| 摘 要： | 目的观察吉西他滨单药治疗老年晚期非小细胞肺癌的疗效、临床受益反应（CBR）及毒副反应。方法34例经病理学或细胞学确诊的老年非小细胞肺癌患者（≥60岁），应用吉西他滨1000mg／m^2，静脉滴注，第1，8天给药，每21天为1周期；对照组给予最佳支持治疗（BSC）。结果吉西他滨治疗组有效率（RR）为26．5％，中位缓解时间为6．2个月，中位肿瘤进展时间（TTP）为5．4个月，中位生存期（OS）为11．2个月，1年生存率为38．2％；对照组有效率（RR）为0％，中位TTP为2．4个月，中位OS为4．8个月，1年生存率为9．7％。治疗组临床受益反应较对照组均有明显提高（P〈0．01）。治疗组药物毒副反应较轻，无不良反应需停药者。结论吉西他滨单药治疗老年晚期非小细胞肺癌疗效明确，毒副反应较轻，耐受性较好。
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| 关 键 词： | 非小细胞肺癌 老年 吉西他滨 |
The observation of efficiency of gemcitabine single-agent in the treatment of elderly patients with advanced non-small cell lung cancer |
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| JiANG Hong-ning,YU Min. The observation of efficiency of gemcitabine single-agent in the treatment of elderly patients with advanced non-small cell lung cancer[J]. Journal of Clinical Pulmonary Medicine, 2009, 14(2): 196-197 |
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| Authors: | JiANG Hong-ning YU Min |
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| Affiliation: | . (Department of Oncology, Beijing Geriatric Hospital, Beijing 100095, China) |
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| Abstract: | Objective To observe the efficacy,clinical benefit response(CBR)and drug-related toxicity of gemcitabine single-agent in the treatment of elderly patients with advanced non-small cell lung cancer.Methods 34 elderly patients with histologically or cytologically diagnosed non-small cell lung cancer were treated with gemcitabine(a dose of 1000 mg/m2 was infused on day1 and 8,with 21days as one cycle).Control group(n=31),used best supportive care(BSC).Results The response rate of the gemcitabine group was 26.5%... |
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| Keywords: | non-small-cell lung cancer elderly gemcitabine |
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