Absence of malaria mortality in villagers with chloroquine-resistant Plasmodium falciparum treated with chloroquine |
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Authors: | S L Hoffman,S Masbar,P R Hussein,A Soewarta,S Harun,H A Marwoto,J R Campbell,L Smrkovski,I Purnomo Y" >Wiady |
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Affiliation: | 1. U.S. Naval Medical Research Unit No. 2, Jakarta Detachment, APO San Francisco 96356, USA;2. Nusa Tenggara Timur Provincial Health Service, Indonesia;3. The National Institute of Health Research and Development, Indonesia;4. U.S. Naval Medical Research Unit No. 2, APO San Francisco 96528, USA |
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Abstract: | We carried out a series of malaria studies in Robek , Flores, Indonesia, a coastal village of 900 farmers and fishermen where malaria is hyperendemic by parasite rate and holoendemic by spleen rate. The studies showed that: (i) 28 of 31 isolates (90%) of Plasmodium falciparum were resistant to chloroquine in vitro, (ii) 3 of 12 isolates (25%) were resistant at the R-11 level in vivo, (iii) 376 P. falciparum infections occurred in 301 individuals during one year, (iv) no villagers who were treated with chloroquine for P. falciparum infections during the year died, and (v) increasing the dosage of chloroquine base from 15 to 25 to 37.5 mg/kg led to improved clearing of parasitaemia. We conclude that chloroquine can still be used as the primary antimalarial in Robek , but the dosage may have to be increased to clear parasitaemia. |
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Keywords: | Address reprint requests to: Publications Office U.S. Naval Medical Research Unit No. 2 APO San Francisco CA 96528 USA. |
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