S100A4蛋白和上皮钙粘素在宫颈鳞癌中的表达及意义

目的:探讨S100A4蛋白和上皮钙粘素(E-cad)在宫颈鳞癌组织中的表达及其临床意义。方法:采用免疫组织化学SP法检测65例宫颈鳞癌组织和10例正常宫颈组织中S100A4蛋白和E-cad的表达水平。结果:(1)宫颈鳞癌组织中S100A4蛋白和E-cad的表达率分别为35.4%(23/65)和33.8%(22/65);与正常宫颈组织比较,差异具有显著性(P<0.01);(2)S100A4蛋白在宫颈鳞癌中的表达与临床分期及淋巴结转移有关(P<0.05);与组织学分级无关(P>0.05);E-cad表达与淋巴结转移和组织学分级有关(P<0.05),与临床分期无关(P>0.05);(3)S100A4蛋白和E-cad在宫颈鳞癌组织的表达呈负相关(r=-0.257,P<0.05)。结论:S100A4蛋白和E-cad与宫颈鳞癌浸润和转移相关;S100A4蛋白可作为判定宫颈鳞癌临床病理特征的重要指标之一。

Expression and significance of S100A4 and E-cadherin in cervical squamous carcinoma.

Objective:To investigate the expression and significance of S100A4 protein and E-cadherin in cervical squamous carcinoma.Methods:The SP immunohistochemical method was used to detect the expression of S100A4 and E-cadherin in 65 cases of cervical squamous carcinoma and 10 cases of normal cervical tissues. Results:(1) The positive expression rates of S100A4 and E-cadherin were 35.4%(23/65) and 33.8%(22/65)in cervical squamous carcinoma,respectively.There were significant differences between cervical squamous carcinoma and normal group.(2) The expression of S100A4 was positively correlated with the clinical stage and lymph node metastases(P<0.05),but not with grade of tumor(P>0.05);E-cadherin expression was correlated with lymph node metastasis and the grade of tumor(P<0.05),but not with the clinical stage(P>0.05).(3) The expression of S100A4 was negatively correlated to E-cadherin in cervical squamous carcinoma(r=-0.257,P<0.05).Conclusions:There is a close relationship between the expression of S100A4 and E-cadherin and the invasion and metastasis of cervical carcinoma;S100A4 may be an important predictor of the clinicopathologic features of cervical carcinoma.