| 血清肿瘤标志物检测在肺癌诊断中的临床价值 |
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| 引用本文： | 朱景倩,朱丹,陈慧,骆健峰,盛琳.血清肿瘤标志物检测在肺癌诊断中的临床价值[J].中国卫生检验杂志,2010(1). |
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| 作者姓名： | 朱景倩 朱丹 陈慧 骆健峰 盛琳 |
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| 作者单位： | 浙江省金华市中心医院呼吸科; |
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| 摘 要： | 目的:探讨7种肿瘤标志物在肺癌患者血清中的水平及其在肺癌鉴别诊断中的价值。方法:采用化学发光法对116例肺癌患者和30例健康人血清中糖类抗原125(CA125)、糖类抗原15-3(CA15-3)、糖类抗原19-9(CA19-9)、细胞角蛋白19片段(Cyfra21-1)、神经元特异性烯醇化酶(NSE)、癌胚抗原(CEA)、鳞癌抗原(Scc)的含量进行检测及比较。结果:肺癌患者的7种血清肿瘤标志物水平均明显高于健康人组,差异均有统计学意义(P0.05)。其中,CA125、CA15-3、CA19-9、CEA在腺癌中水平明显高于其他类型肺癌(P0.05),Scc在鳞癌中水平明显高于腺癌与小细胞肺癌(P0.05),Cyfra21-1在鳞癌及腺癌中高于小细胞肺癌,但鳞癌与腺癌之间无差别(P0.05),NSE在小细胞肺癌中呈现高表达,明显高于鳞癌与腺癌(P0.05)。7种肿瘤标志物联合检测阳性率高达94.83%,准确度达89.73%,高于单项检测(P0.05)。结论:7项肿瘤标志物对肺癌的检测都有一定意义,不同病理类型各有特点,为肺癌的鉴别诊断提供依据,联合检测可提高肺癌诊断的灵敏度和准确度。
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| 关 键 词： | 肺肿瘤 肿瘤标志物 诊断 |
Clinical value of serum tumor markers in diagnosis of lung cancer |
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| ZHU Jin-qian,ZHU Dan,CHEN Hui,LUO Jian-feng,SHENG Lin.Clinical value of serum tumor markers in diagnosis of lung cancer[J].Chinses Journal of Health Laboratory Technology,2010(1). |
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| Authors: | ZHU Jin-qian ZHU Dan CHEN Hui LUO Jian-feng SHENG Lin |
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| Institution: | ZHU Jin-qian,ZHU Dan,CHEN Hui,LUO Jian-feng,SHENG Lin (Respriatory Diseases Department of the Jinhua Central Hospital,Jinhua 321000,China) |
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| Abstract: | Objective:To investigate the serum levels of 7 tumor markers and evaluate the clinical value of them in differential diagnosis of lung cancer.Methods:The levels of CA125,CA15-3,CA19-9,Cyfra21-1,NSE,CEA,Scc were assayed and compared between the lung cancer group(116 cases) and normal control group(30 cases) by electrochemiluminesence immunoassay.Results:The levels of the seven tumor markers in patients with lung cancer were remarkably higher than those in healthy adults(P<0.05).The levels of CA125,CA15-3,CA1... |
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| Keywords: | Lung carcinoma Tumor marker Diagnosis |
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