碘和硒对甲状腺作用的实验研究

本实验采用3×3析因实验设计,将360只小鼠分成9个实验组,分3个月和6个月两个实验期,以不同浓度的碘、硒单独及联合作用对甲状腺功能、形态结构及甲状腺肿发生和发展的影响进行了探讨。结果:(1)低碘和高碘是甲状腺功能、形态结构及甲状腺肿发生和发展的主要因素;(2)低硒长时间(6个月)作用可促进甲状腺肿的发生,补硒则使甲状腺重量降低,补至高剂量时作用更明显;(3)碘硒交互作用的结果与碘单独作用基本一致。在高碘时,补硒可使甲状腺素(T_4)调剂到适碘组的水平。因此,在对地甲病进行流行病学调查和防治时应重视硒的作用。同时硒对碘性甲亢是否有预防作用值得深入探讨。

The Effect of Iodine and Selenium on Thyroid Gland

This study was conducted to determine the effect of iodine and selenium at different levels on thyroid gland. Three times three factorial experiment design was used. Three hundred and sixty mice were randomly divided into 9 groups and sacrificed at 3 and 6 months' end. Thyroid function, morphosis and ultrastructure, and the changes of goitrogenic were observed. The following results were obtained. (1) Iodine deficiency and excess were main causes of the changes of thyroid function, morphosis and ultrastructure and goitrogenic. (2)Selenium deficiency might enhance goitrogenic of iodine at six months' end. Selenium supplementation, especially 1500 ppb decreased thyroid weight. (3) The united effects of iodine and selenium were the same as those of iodine. Selenium supplementation might regulate serum T4 level of iodine excess group to that of iodine medium group. The results indicate that selenium play a significant role in the etiology and preventive of goiter, suggesting the possibility of selenium