热带地区土源性线虫病感染连续化疗后的疗效观察

本文选用噻嘧啶、阿苯达唑、甲苯达唑和左旋咪唑等驱虫药物，在热带地区的海南省琼海市朝烈村委会现场，采用改良加藤涂片法和试管滤纸培养法对居民普查粪检，两年连续6次化疗驱虫普治（第1年4次，第2年2次），对钩虫、蛔虫、鞭虫等土源性线虫病感染者观察疗效。结果钩虫和蛔虫感染者的疗效甚佳，钩虫的虫卵阴转率高达96．4％，残存的5例美洲钩虫感染者，克粪虫卵数大幅度减少，均在300个以内，蛔虫的虫卵阴转率高达99．3％，克粪虫卵数为24个；其疗效与选用驱虫药物和安排服药间隔时间有关。鞭虫感染者的疗效不甚理想，虫卵阴转率仅63．3％，可能与选用的几种驱虫药，只有甲苯达唑对鞭虫感染者有一定疗效，而本文的各个疗程的剂量都均偏低有关。

CONSECUTIVE CHEMOTHERA-PEUTIC EFFECT ON PATIENTS WITH SOIL-BORNE NEMATHELMI NTHISTS IN THE TROPICAL ZONE

The study investigated the chemotherapeutic effect of pyrantel pamoate, albendazole, mebendazole and other drugs in 6consecutive courses in 2 years on patients with hookworm, ascaris, trichuris and other soil - borne nemathelminth in the field of Chaolie Village, Qionghai City, Hainan Province, The results showed that the chemotherapeutic effect on patients with hookworm and ascaris was very satisfactory, the curative rate for hookworm infection was 96. 4%, there were less than 300 eggs/g in each faeces of the 5 residual patients with Necator americanus; the curative rate for ascaris infection was as high as 99. 3%,there were 24 eggs/g of faeces. It showed that the effect was related to the drugs chosen and the interval of medication arranged.The effect on patients with trichuris infection was not satisfactory with a curativerate of 63. 3%. This might be related to the low doses of the chosen anthelmintics in which only mebendazole showed certain effect on trichuris infection.