| p53野生型与突变型上皮性卵巢癌临床病理特征比较 |
| |
| 引用本文： | 任爱民,侯英勇,许华,屠蕊沁.p53野生型与突变型上皮性卵巢癌临床病理特征比较[J].中国临床医学,2009,16(2):247-248. |
| |
| 作者姓名： | 任爱民 侯英勇 许华 屠蕊沁 |
| |
| 作者单位： | 1. 复旦大学附属中山医院妇产科,上海,200032
2. 复旦大学附属中山医院病理科,上海,200032 |
| |
| 摘 要： | 目的：探讨p53基因野生型和突变型上皮性卵巢癌的临床病理特征差异。方法：收集经手术病理证实的上皮性卵巢癌病例105例,按免疫组化方法检测癌组织中p53蛋白表达将其分为p53野生型组和突变型组,比较两组发病年龄、病理分期、组织学分类和分化程度等特征。结果：p53野生型组和突变型组卵巢肿块平均长径分别为13.2±7.8cm与8.5±5.4cm,前者显著大于后者（P〈0.01）。p53野生型组I期患者占60.0%,p53突变型组晚期患者占64.3%。野生型组卵巢浆液性癌、内膜样癌、透明细胞癌的比例相似,都在25%左右;而p53突变型组高达67.1%的病理类型为浆液性癌。两组患者的肿瘤分期和病理类型构成比有显著性差异。两组患者年龄、肿瘤累及双侧的比率以及组织学分级均无统计学显著差异。结论：p53基因的突变与上皮性卵巢癌的发生密切相关,但是它在不同病理类型的上皮性卵巢癌的发生中所起的作用是不同的。
|
| 关 键 词： | p53突变 上皮性卵巢癌 |
Comparison of p53 Wild-type and Mutated Clinicopathological Characteristics in Epithelial Ovarian Cancer |
| |
| REN Aimin,HOU Yingyong,XU Hua,TU Ruiqin.Comparison of p53 Wild-type and Mutated Clinicopathological Characteristics in Epithelial Ovarian Cancer[J].Chinese Journal Of Clinical Medicine,2009,16(2):247-248. |
| |
| Authors: | REN Aimin HOU Yingyong XU Hua TU Ruiqin |
| |
| Institution: | REN Aimin HOU Yingyong XU Hua TU Ruiqin Department of Obstetrics & Gynaecology,Department of Pathology,Zhongshan Hospital,Fudan University,Shanghai 200032 |
| |
| Abstract: | Objective:To explore the difference of clinical and pathological characteristics between wild-type and mutated p53 in epithelial ovarian cancer. Methods:The data of patients of epithelial ovarian cancer with operative and histologically-confirmed were colected. According the expression of p53 protein in epithelial ovarian cancer tissue detected using immunohistochemistry, patients were divided into wild-type group and mutated group.Results:The mean size of ovarian tumour in p53 wild-type group and mutated g... |
| |
| Keywords: | P53 mutation Epithelial ovarian cancer |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
