Lymphoproliferative responses to recombinant HIV-1 envelope antigens in neonates and infants receiving gp120 vaccines. AIDS Clinical Trial Group 230 Collaborators |
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Authors: | Borkowsky W Wara D Fenton T McNamara J Kang M Mofenson L McFarland E Cunningham C Duliege A M Francis D Bryson Y Burchett S Spector S A Frenkel L M Starr S Van Dyke R Jimenez E |
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Institution: | The Saul Krugman Division of Infectious Diseases and Immunology, New York University Medical School, New York, NY 10016, USA. borkow01@mcgc16.med.nyu.edu |
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Abstract: | Children of mothers infected with human immunodeficiency virus type 1 (HIV-1) were immunized at birth and at 1, 3, and 5 months with 1 of 3 doses of recombinant gp120 vaccines prepared from SF-2 or MN strains of HIV-1. A total of 126 children were not infected; 21 received adjuvant only. Vaccine recipients developed lymphoproliferative responses on >/=2 occasions, responding more often to homologous HIV-1 antigens than did adjuvant recipients (56% vs. 14%; P<.001). Responses were appreciated after 2 immunizations and were maintained for >84 weeks after the last immunization. An accelerated immunization schedule (birth, 2 weeks, 2 months, and 5 months) with the lowest dose of the SF-2 vaccine produced responses in all 11 vaccinees by 4 weeks. Responses to heterologous envelope antigens were also detected. Immune responses to vaccination are achievable at an age when some infection (perinatal or breast milk exposure related) may be prevented. |
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