| 大剂量甲氨蝶呤化疗的脑脊液药代动力学研究 |
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| 引用本文： | 赵帆,王琦,赵永新,徐雪芳,邵欢,周秋华.大剂量甲氨蝶呤化疗的脑脊液药代动力学研究[J].中德临床肿瘤学杂志,2006,5(2):101-103. |
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| 作者姓名： | 赵帆 王琦 赵永新 徐雪芳 邵欢 周秋华 |
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| 作者单位： | 赵帆 (南京医科大学附属无锡第二医院肿瘤科,214002)； 王琦 (南京医科大学附属无锡第二医院肿瘤科,214002)； 赵永新 (南京医科大学附属无锡第二医院肿瘤科,214002)； 徐雪芳 (南京医科大学附属无锡第二医院肿瘤科,214002)； 邵欢 (南京医科大学附属无锡第二医院肿瘤科,214002)； 周秋华 (南京医科大学附属无锡第二医院肿瘤科,214002)； |
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| 摘 要： |
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| 关 键 词： | 甲氨蝶呤/药代动力学 色谱法 高效液相/方法 输注 静脉内 |
| 收稿时间： | 2005-10-12 |
| 修稿时间： | 2006-01-09 |
Cerebrospinal Fluid Pharmacokinetics of Intravenous High
Dose-Methotrexate |
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| Fan ZHAO,Qi WANG,Yongxin ZHAO,Xuefang XU,Huan SHAO,Qiuhua ZHOU.Cerebrospinal Fluid Pharmacokinetics of Intravenous High
Dose-Methotrexate[J].The Chinese-German Journal of Clinical Oncology,2006,5(2):101-103. |
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| Authors: | Fan ZHAO Qi WANG Yongxin ZHAO Xuefang XU Huan SHAO Qiuhua ZHOU |
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| Institution: | (1) Department of Oncology, Affiliated Wuxi Second Hospital of Nanjing Medical University, 214002 Wuxi, China;(2) Department of Pharmacy, Affiliated Huaihua Hospital of Nanhua University, 418000 Huaihua, China;(3) Department of Pharmacy, Affiliated Wuxi Second Hospital of Nanjing Medical University, 214002 Wuxi, China |
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| Abstract: | Objective: To study the cerebrospinal fluid pharmacokinetics of intravenously administered high
dose-methotrexate (HD-MTX) and provide a solid fundament for clinical practice. Methods: MTX at a
high dose ranging from 1.0 to 3.0 g per course was intravenously administered to 30 patients with malignant
tumors. Blood and CSF samples were consecutively collected up to 36 h after the initiation of infusion
(6 h). MTX concentrations were measured by using a reversed phase high-performance liquid chromatography
(RP-HPLC) assay. Results: CSF MTX concentrations were (1.65±1.52)×10-6, (4.3±3.34)×10-7,
(1.46±1.10)×10-7 and (3.19±4.38)×10-8 mol/L, respectively, at 0, 6, 12 and 24 h post infusion, and became
undetectable at 36 h post infusion. The concentration-time curve of CSF MTX closely resembled
that of the plasma MTX and fitted with the following linear regression equation: Ŷ=0.057 97+0.010 82X
(Ŷ: CSF MTX concentration, X: Plasma MTX concentration, r=0.8357). Conclusion: CSF MTX was
metabolized in a linear two-compartment model. Additionally, pharmacokinetic analysis of MTX levels
indicated a positive correlation between CSF MTX and plasma MTX levels. |
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| Keywords: | methotrexate/pharmacokinetics chromatography high-performance liquid/method infusion intravenous |
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